Electrochemical oxidative cyclization of activated alkynes with diselenides or disulfides: access to functionalized coumarins or quinolinones

被引：108

作者：

Hua, Jiawei ^{[1
]}

Fang, Zheng ^{[1
]}

Xu, Jia ^{[1
]}

Bian, Mixue ^{[1
]}

Liu, ChengKou ^{[1
]}

He, Wei ^{[1
]}

Zhu, Ning ^{[1
]}

Yang, Zhao ^{[2
]}

Guo, Kai ^{[1
,3
]}

机构：

[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Puzhu Rd S, Nanjing 211816, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Coll Engn, 24 Tongjiaxiang, Nanjing 210003, Jiangsu, Peoples R China

[3] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, 30 Puzhu Rd S, Nanjing 211816, Jiangsu, Peoples R China

来源：

GREEN CHEMISTRY | 2019年 / 21卷 / 17期

基金：

美国国家科学基金会;

关键词：

BIOLOGICAL EVALUATION; SULFINIC ACIDS; SPIROCYCLIZATION; ALKENES; DIFUNCTIONALIZATION; ARYLPROPIOLAMIDES; SELENYLATION; DERIVATIVES; GENERATION; CHEMISTRY;

D O I：

10.1039/c9gc02131k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A direct electrochemical oxidative cyclization of alkynoates and alkynamides with diselenides or disulfides for the synthesis of coumarins and quinolinones bearing a chalcogen functional group has been developed. This green and efficient approach was realized through a constant current electrolysis in an undivided cell under metal-free and oxidant-free conditions. Moreover, a series of selenium/sulfur-substituted coumarin and quinolinone products were obtained in moderate to good yields with a broad scope and functional group tolerance.

引用

页码：4706 / 4711

页数：6

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