T cell receptor repertoire as a potential diagnostic marker for celiac disease

被引：12

作者：

Yao, Ying ^{[1
,2
]}

Zia, Asima ^{[1
,4
]}

Neumann, Ralf Stefan ^{[1
,2
]}

Pavlovic, Milena ^{[3
]}

Balaban, Gabriel ^{[3
]}

Lundin, Knut E. A. ^{[2
,5
]}

Sandve, Geir Kjetil ^{[2
,3
]}

Qiao, Shuo-Wang ^{[1
,2
]}

机构：

[1] Univ Oslo, Dept Immunol, Inst Clin Med, Oslo, Norway

[2] Univ Oslo, KG Jebsen Coeliac Dis Res Ctr, Oslo, Norway

[3] Univ Oslo, Dept Informat, Oslo, Norway

[4] King Abdullah Univ Sci & Technol, Living Syst Lab, Thuwal, Saudi Arabia

[5] Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway

来源：

CLINICAL IMMUNOLOGY | 2021年 / 222卷

关键词：

Celiac disease; CD4+T cells; TCR repertoire; Disease inference; High-throughput sequencing; DISCORDANT; CONCORDANT; FREQUENCY;

D O I：

10.1016/j.clim.2020.108621

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences.

引用

页数：7

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