Heterocyclic synthesis using nitrilimines. Part 13: Synthesis of new 1,2,3,4-tetrahydro-s-tetrazine derivatives

被引：3
|
作者：
Dalloul, Hany M. M. [1 ]
机构：
[1] Al Aqsa Univ Gaza, Fac Sci Appl, Dept Chem, IL-76888 Gaza, Israel
来源：
TETRAHEDRON | 2009年 / 65卷 / 42期
关键词：
s-Tetrazines; Formazanes; Nitrilimines; Electrophilic addition; Cyclization; ANTITUMOR-ACTIVITY; NITRILE IMINES; S-TETRAZINE;
D O I：
10.1016/j.tet.2009.08.036
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of C-aroyl-N-arylnitrilimines with 1,1-dimethylhydrazine or 1-methyl-1-phenylhydrazine led to the formation of the acyclic electrophilic addition products, which underwent thermal oxidative cyclization at CH3 to 1,2,3,4-tetrahydro-s-tetrazines. Both analytical and spectroscopic data of all the synthesized compounds are in full agreement with the proposed structures. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8722 / 8726
页数：5
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