Heterocyclic synthesis using nitrilimines. Part 13: Synthesis of new 1,2,3,4-tetrahydro-s-tetrazine derivatives

被引：3

作者：

Dalloul, Hany M. M. ^{[1
]}

机构：

[1] Al Aqsa Univ Gaza, Fac Sci Appl, Dept Chem, IL-76888 Gaza, Israel

来源：

TETRAHEDRON | 2009年 / 65卷 / 42期

关键词：

s-Tetrazines; Formazanes; Nitrilimines; Electrophilic addition; Cyclization; ANTITUMOR-ACTIVITY; NITRILE IMINES; S-TETRAZINE;

D O I：

10.1016/j.tet.2009.08.036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of C-aroyl-N-arylnitrilimines with 1,1-dimethylhydrazine or 1-methyl-1-phenylhydrazine led to the formation of the acyclic electrophilic addition products, which underwent thermal oxidative cyclization at CH3 to 1,2,3,4-tetrahydro-s-tetrazines. Both analytical and spectroscopic data of all the synthesized compounds are in full agreement with the proposed structures. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：8722 / 8726

页数：5

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