Zwitterionic diketopyrrolopyrrole for fluorescence/photoacoustic imaging guided photodynamic/photothermal therapy

被引:30
作者
Deng, Weixing [1 ,2 ]
Wu, Qi [1 ,2 ]
Sun, Pengfei [1 ,2 ]
Yuan, Pengcheng [1 ,2 ]
Lu, Xiaomei [3 ]
Fan, Quli [1 ,2 ]
Huang, Wei [3 ]
机构
[1] Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat IAM, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat IAM, Jiangsu Key Lab Biosensors, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China
[3] Northwestern Polytech Univ, Shaanxi Inst Flexible Elect SIFE, 127 West Youyi Rd, Xian 710072, Shaanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; IN-VIVO; HIGHLY EFFICIENT; CANCER; NANOPARTICLES; NANOPLATFORM; CORE; NANOCOMPOSITES; CHEMOTHERAPY;
D O I
10.1039/c8py00244d
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Dual-modal imaging and dual-modal therapy provide multiple complementary theranostic features. The theranostic agent has favorable renal excretion and low cytotoxicity, making it of great interest in the nanomedical field. Herein, a water-soluble conjugated zwitterionic polymer (DPP-SPMA) with low-fouling and low cytotoxicity was prepared and used for fluorescence/PA imaging guided PTT/PDT therapy. The in vivo imaging results showed that the DPP-SPMA had excellent enhanced permeability and retention effects. The fluorescence imaging demonstrated that the DPP-SPMA was excreted by renal metabolism because the controlled molecular mass was less than the renal filtration threshold. The DPP-SPMA shows a photothermal effect under 730 nm irradiation and an excellent singlet oxygen generation capacity for the PDT therapy under 635 nm irradiation. The high accumulation of DPP-SPMA by passive targeting around the tumor stimulated excellent synergistic photodynamic therapy and photothermal therapy. As a result, the water-soluble zwitterion DPP-SPMA was well suited for fluorescence/PA dual-modal imaging and had significant antitumor activity in vivo via synergistic photodynamic therapy and photothermal therapy.
引用
收藏
页码:2805 / 2812
页数:8
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