Synthesis of Hollow Silica Nanospheres by the Intermolecular Interactions within Amphiphilic Block Copolymer Micelle Templates

被引：0

作者：

Cheng Xiao ^{[1
]}

Qiu Ke-xin ^{[1
]}

Hu Jin-wei ^{[1
]}

Zhou Xiao-jun ^{[1
]}

Chen Meng-xia ^{[1
]}

He Chuang-long ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai, Peoples R China

来源：

2012 INTERNATIONAL FORUM ON BIOMEDICAL TEXTILE MATERIALS, PROCEEDINGS | 2012年

关键词：

Hollow mesoporous silica nanoparticles; Amphiphilic block copolymer micelle; Thickness of shell; Doxorubicin; Drug delivery; NANOPARTICLES; RELEASE; SPHERES;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this work, hollow mesoporous silica nanoparticles (HMSNs) have been successfully synthesized in a facile route using PS-b-PAA and CTAB as co-templates at room temperature. The shell thickness of the synthesized HMSNs could be tailored by changing the addition rate of the silica source, and the poperties of these nanoparticles were then characterized by using XRD, N-2 adsorption-desorption analysis, TEM and UV-vis analysis. Furthermore, Doxorubicin (DOX)-loaded HMSNs (DMSNs) show an effective drug loading and a pH-responsive drug release property.

引用

页码：12 / 15

页数：4

共 8 条

[1] Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles [J].

Gao, Yu ;

Chen, Yu ;

Ji, Xiufeng ;

He, Xinyu ;

Yin, Qi ;

Zhang, Zhiwen ;

Shi, Jianlin ;

Li, Yaping .

ACS NANO, 2011, 5 (12) :9788-9798

[2] Core/shell gold nanoparticles by self-assembly and crosslinking of micellar, block-copolymer shells [J].

Kang, YJ ;

Taton, TA .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (03) :409-412

[3] Multifunctional Mesoporous Silica Nanocomposite Nanoparticles for Theranostic Applications [J].

Lee, Ji Eun ;

Lee, Nohyun ;

Kim, Taeho ;

Kim, Jaeyun ;

Hyeon, Taeghwan .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :893-902

[4]

Mathlowitz E, 1997, J NATURE, V386, P410

[5] Synthesis of Core-Shell Structured Dual-Mesoporous Silica Spheres with Tunable Pore Size and Controllable Shell Thickness [J].

Niu, Dechao ;

Ma, Zhi ;

Li, Yongsheng ;

Shi, Jianlin .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (43) :15144-15147

[6] Novel Hollow Mesoporous Silica Spheres/Polymer Hybrid Membrane for Ultrafiltration [J].

Wu, Huiqing ;

Tang, Beibei ;

Wu, Peiyi .

JOURNAL OF PHYSICAL CHEMISTRY C, 2012, 116 (03) :2246-2252

[7] Mesoporous Silica Nanoparticle-Based Double Drug Delivery System for Glucose-Responsive Controlled Release of Insulin and Cyclic AMP [J].

Zhao, Yannan ;

Trewyn, Brian G. ;

Slowing, Igor I. ;

Lin, Victor S. -Y. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (24) :8398-+

[8] A facile method to synthesize novel hollow mesoporous silica spheres and advanced storage property [J].

Zhu, YF ;

Shi, JL ;

Chen, HR ;

Shen, WH ;

Dong, XP .

MICROPOROUS AND MESOPOROUS MATERIALS, 2005, 84 (1-3) :218-222

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