High-molecular weight adiponectin isoforms increase after biliopancreatic diversion in obese subjects

被引:42
作者
Salani, Barbara
Briatore, Lucia
Andraghetti, Gabriella
Adami, Gian Franco
Maggi, Davide
Cordera, Renzo
机构
[1] Univ Genoa, Dept Endocrinol & Metab, Genoa, Italy
[2] Univ Genoa, Dept Surg, Genoa, Italy
关键词
adiponectin; bariatric surgery; biliopancreatic diversion; weight loss; light-molecular weight adiponectin;
D O I
10.1038/oby.2006.174
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Our objective was,to test the effect of biliopancreatic diversion (BDP) in adiponectin multimerization. Adiponectin, the major protein secreted by adipose tissue, circulates in plasma in different isoforms. The most clinically relevant oligomers are high-molecular weight (HMW) multimers and low-molecular weight (LMW)-trimers. Contrasting data on the effect of weight loss on adiponectin isoforms have been reported. Research Methods and Procedures: We measured total plasma adiponectin and HMW and LMW adiponectin oligomers (by Western blot analysis) before and 1 month after BPD, in 18 severely obese subjects. Results: One month after BPD, body weight decreased similar to 11%. Total adiponectin showed significant increase after BPD. In addition, we found a significant increase in HMW (percentage) adiponectin oligomers. We found a significant inverse correlation between HMW (percentage) and BMI before and after BPD. Homeostasis model of assessment-insulin resistance decreased significantly after the BPD, without any significant correlation with total serum adiponectin and adiponectin oligomers. Discussion: A moderate weight loss after BPD increases total and HMW adiponeetin oligomers. The significant correlation between BMI and HMW (percentage) adiponectin oligomers but not between BMI and total adiponectin might indicate a role of body fat mass in regulation of adiponectin multimerization. These data suggest that HMW oligomers represent a very sensitive parameter to short-term BMI changes after BPD.
引用
收藏
页码:1511 / 1514
页数:4
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