Cytomegalovirus and ulcerative colitis: Place of antiviral therapy
被引:76
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作者:
Pillet, Sylvie
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机构:
Univ Lyon, Fac Med St Etienne, GIMAP, EA3064, F-69365 Lyon 7, France
Univ Hosp St Etienne, Lab Infect Agents & Hyg, F-42025 St Etienne 2, FranceUniv Lyon, Fac Med St Etienne, GIMAP, EA3064, F-69365 Lyon 7, France
Pillet, Sylvie
[1
,2
]
Pozzetto, Bruno
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机构:
Univ Lyon, Fac Med St Etienne, GIMAP, EA3064, F-69365 Lyon 7, France
Univ Hosp St Etienne, Lab Infect Agents & Hyg, F-42025 St Etienne 2, FranceUniv Lyon, Fac Med St Etienne, GIMAP, EA3064, F-69365 Lyon 7, France
Pozzetto, Bruno
[1
,2
]
Roblin, Xavier
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Univ Lyon, Fac Med St Etienne, GIMAP, EA3064, F-69365 Lyon 7, FranceUniv Lyon, Fac Med St Etienne, GIMAP, EA3064, F-69365 Lyon 7, France
Roblin, Xavier
[1
]
机构:
[1] Univ Lyon, Fac Med St Etienne, GIMAP, EA3064, F-69365 Lyon 7, France
[2] Univ Hosp St Etienne, Lab Infect Agents & Hyg, F-42025 St Etienne 2, France
The link between cytomegalovirus (CMV) infection and inflammatory bowel diseases remains an important subject of debate. CMV infection is frequent in ulcerative colitis (UC) and has been shown to be potentially harmful. CMV reactivation needs to be diagnosed using methods that include in situ detection of viral markers by immunohistochemistry or by nucleic acid amplification techniques. Determination of the density of infection using quantitative tools (numbers of infected cells or copies of the genome) is particularly important. Although CMV reactivation can be considered as an innocent bystander in active flare-ups of refractory UC, an increasing number of studies suggest a deleterious role of CMV in this situation. The presence of colonic CMV infection is possibly linked to a decreased response to steroids and other immunosuppressive agents. Some treatments, notably steroids and cyclosporine A, have been shown to favor CMV reactivation, which seems not to be the case for therapies using anti-tumor necrosis factor drugs. According to these findings, in flare-ups of refractory UC, it is now recommended to look for the presence of CMV reactivation by using quantitative tools in colonic biopsies and to treat them with ganciclovir in cases of high viral load or severe disease.
机构:
Rockefeller Univ, Howard Hughes Med Inst, Strang Lab Apoptosis & Canc Biol, New York, NY 10021 USA
Hadassah Hebrew Univ, Med Ctr, IBD Unit, Inst Gastroenterol & Liver Dis, POB 12000, IL-91120 Jerusalem, IsraelRockefeller Univ, Howard Hughes Med Inst, Strang Lab Apoptosis & Canc Biol, New York, NY 10021 USA
Levin, Avi
Yaari, Shaul
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Hadassah Hebrew Univ, Med Ctr, IBD Unit, Inst Gastroenterol & Liver Dis, POB 12000, IL-91120 Jerusalem, IsraelRockefeller Univ, Howard Hughes Med Inst, Strang Lab Apoptosis & Canc Biol, New York, NY 10021 USA
Yaari, Shaul
Stoff, Ronen
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Hadassah Hebrew Univ, Med Ctr, IBD Unit, Inst Gastroenterol & Liver Dis, POB 12000, IL-91120 Jerusalem, IsraelRockefeller Univ, Howard Hughes Med Inst, Strang Lab Apoptosis & Canc Biol, New York, NY 10021 USA
Stoff, Ronen
Caplan, Orit
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机构:
Hadassah Hebrew Univ, Med Ctr, Clin Virol Unit, Dept Clin Microbiol & Infect Dis, Jerusalem, IsraelRockefeller Univ, Howard Hughes Med Inst, Strang Lab Apoptosis & Canc Biol, New York, NY 10021 USA
Caplan, Orit
Wolf, Dana G.
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机构:
Hadassah Hebrew Univ, Med Ctr, Clin Virol Unit, Dept Clin Microbiol & Infect Dis, Jerusalem, IsraelRockefeller Univ, Howard Hughes Med Inst, Strang Lab Apoptosis & Canc Biol, New York, NY 10021 USA
Wolf, Dana G.
Israeli, Eran
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机构:
Hadassah Hebrew Univ, Med Ctr, IBD Unit, Inst Gastroenterol & Liver Dis, POB 12000, IL-91120 Jerusalem, IsraelRockefeller Univ, Howard Hughes Med Inst, Strang Lab Apoptosis & Canc Biol, New York, NY 10021 USA
机构:
Sichuan Univ, West China Hosp, Dept Gastroenterol, 37 Guoxue Alley, Chengdu, Sichuan Provinc, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gastroenterol, 37 Guoxue Alley, Chengdu, Sichuan Provinc, Peoples R China
Yangzhen, S.
Liu, K.
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机构:
Sichuan Univ, West China Hosp, Ctr Infect Dis, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gastroenterol, 37 Guoxue Alley, Chengdu, Sichuan Provinc, Peoples R China
Liu, K.
Xu, T.
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机构:
Sichuan Univ, West China Hosp, Dept Gastroenterol, 37 Guoxue Alley, Chengdu, Sichuan Provinc, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gastroenterol, 37 Guoxue Alley, Chengdu, Sichuan Provinc, Peoples R China
Xu, T.
Yang, Y.
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机构:
Sichuan Univ, West China Hosp, Dept Gastroenterol, 37 Guoxue Alley, Chengdu, Sichuan Provinc, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gastroenterol, 37 Guoxue Alley, Chengdu, Sichuan Provinc, Peoples R China
Yang, Y.
Zhang, Y.
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机构:
Sichuan Univ, West China Hosp, Dept Gastroenterol, 37 Guoxue Alley, Chengdu, Sichuan Provinc, Peoples R ChinaSichuan Univ, West China Hosp, Dept Gastroenterol, 37 Guoxue Alley, Chengdu, Sichuan Provinc, Peoples R China
Zhang, Y.
WEST INDIAN MEDICAL JOURNAL,
2016,
65
(01):
: 229
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231
机构:Kyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Yoshino, Takuya
Nakase, Hiroshi
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机构:
Kyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, JapanKyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Nakase, Hiroshi
Matsuura, Minoru
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机构:Kyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Matsuura, Minoru
Matsumura, Kayoko
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机构:Kyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Matsumura, Kayoko
Honzawa, Yusuke
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机构:Kyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Honzawa, Yusuke
Fukuchi, Takumi
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机构:
Saiseikai Nakatsu Hosp, Dept Gastroenterol & Hepatol, Osaka, JapanKyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Fukuchi, Takumi
Watanabe, Kenji
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机构:
Osaka City Univ, Grad Sch Med, Dept Gastroenterol, Osaka 558, JapanKyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Watanabe, Kenji
Murano, Mitsuyuki
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机构:
Osaka Med Coll, Dept Internal Med 2, Osaka, JapanKyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Murano, Mitsuyuki
Tsujikawa, Tomoyuki
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机构:
Shiga Univ Med Sci, Dept Med, Otsu, Shiga 52021, JapanKyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Tsujikawa, Tomoyuki
Fukunaga, Ken
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机构:
Hyogo Coll Med, Dept Lower Gastroenterol, Nishinomiya, Hyogo 6638501, JapanKyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Fukunaga, Ken
Matsumoto, Takayuki
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机构:
Hyogo Coll Med, Dept Lower Gastroenterol, Nishinomiya, Hyogo 6638501, JapanKyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Matsumoto, Takayuki
Chiba, Tsutomu
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机构:Kyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan