Cytomegalovirus and ulcerative colitis: Place of antiviral therapy

被引:76
|
作者
Pillet, Sylvie [1 ,2 ]
Pozzetto, Bruno [1 ,2 ]
Roblin, Xavier [1 ]
机构
[1] Univ Lyon, Fac Med St Etienne, GIMAP, EA3064, F-69365 Lyon 7, France
[2] Univ Hosp St Etienne, Lab Infect Agents & Hyg, F-42025 St Etienne 2, France
关键词
Human cytomegalovirus; Ulcerative colitis; Inflammatory bowel disease; Ganciclovir; Viral load; Flare-up; Inflammation; Intestinal mucosa; Quantitative polymerase chain reaction; INFLAMMATORY-BOWEL-DISEASE; REAL-TIME PCR; STEM-CELL TRANSPLANTATION; CMV INTESTINAL DISEASE; ACTIVE CROHNS-DISEASE; VIRAL LOAD; ENDOSCOPIC FEATURES; CENTER EXPERIENCE; ADULT PATIENTS; TNF-ALPHA;
D O I
10.3748/wjg.v22.i6.2030
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The link between cytomegalovirus (CMV) infection and inflammatory bowel diseases remains an important subject of debate. CMV infection is frequent in ulcerative colitis (UC) and has been shown to be potentially harmful. CMV reactivation needs to be diagnosed using methods that include in situ detection of viral markers by immunohistochemistry or by nucleic acid amplification techniques. Determination of the density of infection using quantitative tools (numbers of infected cells or copies of the genome) is particularly important. Although CMV reactivation can be considered as an innocent bystander in active flare-ups of refractory UC, an increasing number of studies suggest a deleterious role of CMV in this situation. The presence of colonic CMV infection is possibly linked to a decreased response to steroids and other immunosuppressive agents. Some treatments, notably steroids and cyclosporine A, have been shown to favor CMV reactivation, which seems not to be the case for therapies using anti-tumor necrosis factor drugs. According to these findings, in flare-ups of refractory UC, it is now recommended to look for the presence of CMV reactivation by using quantitative tools in colonic biopsies and to treat them with ganciclovir in cases of high viral load or severe disease.
引用
收藏
页码:2030 / 2045
页数:16
相关论文
共 50 条
  • [31] Diagnosis of Cytomegalovirus Infection during Exacerbation of Ulcerative Colitis
    Levin, Avi
    Yaari, Shaul
    Stoff, Ronen
    Caplan, Orit
    Wolf, Dana G.
    Israeli, Eran
    DIGESTION, 2017, 96 (03) : 142 - 148
  • [32] Cytomegalovirus Reactivation in Ulcerative Colitis Patients: Early Indicators
    Altunal, L. N.
    Ozel, A. S.
    Ak, C.
    NIGERIAN JOURNAL OF CLINICAL PRACTICE, 2023, 26 (06) : 765 - 770
  • [33] Cytomegalovirus colitis complicating ulcerative colitis treated with adalimumab
    Charles, Pierre
    Ackermann, Felix
    Burdy, Gaelle
    Bletry, Olivier
    Leport, Jacques
    Kahn, Jean Emmanuel
    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2010, 45 (04) : 509 - 510
  • [34] Biological therapy for ulcerative colitis
    Arora, Zubin
    Shen, Bo
    GASTROENTEROLOGY REPORT, 2015, 3 (02): : 103 - 109
  • [35] A stool test in patients with active ulcerative colitis helps exclude cytomegalovirus disease
    Magdziak, Agnieszka
    Szlak, Jakub
    Mroz, Andrzej
    Wieszczy, Paulina
    Zagorowicz, Edyta
    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2020, 55 (06) : 664 - 670
  • [36] Synchronous Onset of Cytomegalovirus Colitis and Ulcerative Colitis in an Immunocompetent Patient: A Case Report
    Yangzhen, S.
    Liu, K.
    Xu, T.
    Yang, Y.
    Zhang, Y.
    WEST INDIAN MEDICAL JOURNAL, 2016, 65 (01): : 229 - 231
  • [37] Cytomegalovirus Colitis in a Patient With Ulcerative Colitis
    Akdogan, Ozlem
    Yapar, Derya
    Duzenli, Tolga
    Kaplan, Gulcan
    Tuncel-Ozturk, Pinar
    Ozcerezci, Tugba
    Kocagul-Celikbas, Aysel
    Baykam, Nurcan
    KLIMIK JOURNAL, 2020, 33 (03) : 320 - 323
  • [38] Cytomegalovirus colitis associated with ulcerative colitis
    Rexroth, G
    Rösch, W
    LEBER MAGEN DARM, 2000, 30 (01) : 35 - 38
  • [39] Effect and Safety of Granulocyte-Monocyte Adsorption Apheresis for Patients with Ulcerative Colitis Positive for Cytomegalovirus in Comparison with Immunosuppressants
    Yoshino, Takuya
    Nakase, Hiroshi
    Matsuura, Minoru
    Matsumura, Kayoko
    Honzawa, Yusuke
    Fukuchi, Takumi
    Watanabe, Kenji
    Murano, Mitsuyuki
    Tsujikawa, Tomoyuki
    Fukunaga, Ken
    Matsumoto, Takayuki
    Chiba, Tsutomu
    DIGESTION, 2011, 84 (01) : 3 - 9
  • [40] Complete elimination of cytomegalovirus without antiviral therapy after systemic mesenchymal stromal cell transplantation in a patient with ulcerative colitis (a clinical case)
    Knyazev, O. V.
    Lazebnik, L. B.
    Parfenov, A. I.
    Ruchkina, I. N.
    Shcherbakov, P. L.
    Konoplyannikov, A. G.
    Mikhailova, Z. F.
    Chomeriki, S. G.
    TERAPEVTICHESKII ARKHIV, 2012, 84 (12) : 103 - +