The Cardiac Physiome: perspectives for the future

被引：74

作者：

Bassingthwaighte, James ^{[2
]}

Hunter, Peter ^{[3
]}

Noble, Denis ^{[1
]}

机构：

[1] Dept Physiol Anat & Genet, Oxford OX1 3PT, England

[2] Univ Washington, Seattle, WA 98195 USA

[3] Univ Auckland, Auckland Bioengn Inst, Auckland 1, New Zealand

来源：

EXPERIMENTAL PHYSIOLOGY | 2009年 / 94卷 / 05期

关键词：

ENDOTHELIAL-CELLS; EQUATIONS; TRANSPORT; BEHAVIOR; GROWTH; GENES; HEART; FLOW;

D O I：

10.1113/expphysiol.2008.044099

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The Physiome Project, exemplified by the Cardiac Physiome, is now 10 years old. In this article, we review past progress and future challenges in developing a quantitative framework for understanding human physiology that incorporates both genetic inheritance and environmental influence. Despite the enormity of the challenge, which is certainly greater than that facing the pioneers of the human genome project 20 years ago, there is reason for optimism that real and accelerating progress is being made.

引用

页码：597 / 605

页数：9

共 41 条

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