Quantification of fetal magnetoencephalographic activity in low-risk fetuses using burst duration and interburst interval

被引：6

作者：

Vairavan, Srinivasan ^{[1
]}

Govindan, Rathinaswamy B. ^{[2
]}

Haddad, Naim ^{[3
]}

Preissl, Hubert ^{[4
,5
]}

Lowery, Curtis L. ^{[4
]}

Siegel, Eric ^{[6
]}

Eswaran, Hari ^{[4
]}

机构：

[1] Univ Arkansas, Grad Inst Technol, Little Rock, AR 72204 USA

[2] Childrens Natl Med Ctr, Div Fetal & Transit Med, Washington, DC 20010 USA

[3] Weill Cornell Med Coll Qatar, Doha, Qatar

[4] Univ Arkansas Med Sci, Dept Obstet & Gynecol, SARA Fetal MEG Ctr, Little Rock, AR 72205 USA

[5] Univ Tubingen, Fetal MEG Ctr, Tubingen, Germany

[6] Univ Arkansas Med Sci, Dept Biostat, Little Rock, AR 72205 USA

来源：

CLINICAL NEUROPHYSIOLOGY | 2014年 / 125卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Magnetoencephalography; Fetus; EEG; Quantification; Burst duration; Interburst interval; Brain activity; BRAIN ACTIVITY; PRETERM INFANTS; EEG; MATURATION; NEWBORNS; MAGNETOCARDIOGRAM; PREMATURE; PATTERNS;

D O I：

10.1016/j.clinph.2013.11.018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To identify quantitative MEG indices of spontaneous brain activity for fetal neurological maturation in normal pregnancies and examine the effect of fetal state on these indices. Methods: Spontaneous MEG brain activity was examined in 22 low-risk fetal recordings with gestational age (GA) ranging from 30 to 37 weeks. As major quantitative characteristics of spontaneous activity, burst duration (BD) and interburst interval (IBI) were studied in correlation with GA and fetal state. Results: IBI showed a decrease with gestational age (-0.21 s/week, P = 0.0031). This trend was only maintained in the quiet-sleep state. With respect to BD, no significant trends were detected with GA and state. Conclusion: IBI can be quantified as a fetal brain maturational parameter. The decrease in IBI over gestation was similar to the trend reported in the preterm neonatal EEG studies. Quiet sleep could be the optimal state to study such MEG maturational indices. Significance: With further investigation, indices extracted from spontaneous fetal brain activity may serve as an early warning for fetal neurological distress. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：1353 / 1359

页数：7

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