Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates

被引：6
作者：
Sun, Huihua [1 ]
Zhang, Hongfang [1 ]
Ee Lui Ang [1 ]
Zhao, Huimin [1 ,2 ]
机构：
[1] Agcy Sci Technol & Res, Sci & Engn Inst, Metab Engn Res Lab, Singapore, Singapore
[2] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2018年 / 26卷 / 07期
基金：
美国国家卫生研究院;
关键词：
Biocatalysis; Pharmaceuticals; Pharmaceutical intermediates; Reductases; Oxidases; Hydrolases; Lyases; Isomerases; Transaminases; DYNAMIC KINETIC RESOLUTION; ALDO-KETO REDUCTASE; ONE-POT SYNTHESIS; ASYMMETRIC-SYNTHESIS; CARBONYL REDUCTASE; CHIRAL INTERMEDIATE; EFFICIENT SYNTHESIS; DIRECTED EVOLUTION; GREEN CHEMISTRY; RATIONAL DESIGN;
D O I：
10.1016/j.bmc.2017.06.043
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biocatalysis has been increasingly used for pharmaceutical synthesis in an effort to make manufacturing processes greener and more sustainable. Biocatalysts that possess excellent activity, specificity, ther-mostability and solvent-tolerance are highly sought after to meet the requirements of practical applications. Generating biocatalysts with these specific properties can be achieved by either discovery of novel biocatalysts or protein engineering. Meanwhile, chemoenzymatic routes have also been designed and developed for pharmaceutical synthesis on an industrial scale. This review discusses the recent discoveries, engineering, and applications of biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates. Key classes of biocatalysts include reductases, oxidases, hydrolases, lyases, isomerases, and transaminases. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1275 / 1284
页数：10
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