Human health risk assessment for peroxisome proliferators: More than 30 years of research

被引：23

作者：

Fidaleo, Marco ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Cellular & Dev Biol, I-00185 Rome, Italy

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2009年 / 61卷 / 03期

关键词：

Peroxisome proliferator (PP); Peroxisome proliferator-activated receptor alpha (PPAR alpha); Oxidative stress; Apoptosis; Cell proliferation; Hepatocarcinogenesis; ACTIVATED-RECEPTOR-ALPHA; JUNCTIONAL INTERCELLULAR COMMUNICATION; ACYL-COA OXIDASE; SPECIES-DIFFERENCES; DNA-SYNTHESIS; PPAR-ALPHA; IN-VITRO; CELL-PROLIFERATION; NUCLEAR RECEPTORS; ELEMENT UPSTREAM;

D O I：

10.1016/j.etp.2008.09.002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Substances like gemfibrozil, clofibrate and fenofibrate, widely used in human care for their hypolipidemic effects, belong to a larger class of chemicals called peroxisome proliferators (PPs). PPs, by binding and activing the peroxisome proliferator-activated receptor alpha (PPAR alpha), modulate gene involved in lipid homeostasis both in human and in rodent. In a different way, long term administration of PPs results in hepatocarcinogenesis only in rodent. Although the phenomenon is known since more than 30 years, the exact mechanism is not well understood and the human health risks are not established. In this mini-review is inspected the major findings done in the different species and illustrates the possible doubts for human health by the use of PPs. (c) 2008 Elsevier GmbH. All rights reserved.

引用

页码：215 / 221

页数：7

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