Mesothelin Expression in Pancreatic Mucinous Cysts

被引：9

作者：

Frank, Renee ^{[1
]}

Li, Shaoying ^{[3
]}

Ahmad, Nuzhat A. ^{[2
]}

Sepulveda, Antonia R. ^{[1
]}

Jhala, Nirag C. ^{[1
]}

机构：

[1] Hosp Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Hosp Univ Penn, Dept Gastroenterol, Philadelphia, PA 19104 USA

[3] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL USA

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2014年 / 142卷 / 03期

关键词：

Pancreas; Mesothelin; Mucinous cysts; FINE-NEEDLE-ASPIRATION; ANTIGEN; LESIONS; CANCER; ADENOCARCINOMAS; NEOPLASMS; DIAGNOSIS; MARKER;

D O I：

10.1309/AJCPDTTL2I5ECMFG

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objectives: Mesothelin (MSLN) is a differentiation antigen found to be overexpressed in intraductal papillary mucinous neoplasms (IPMNs) and is a potential treatment target in pancreatic ductal adenocarcinoma. Methods: From institutional archives, 114 cases of resected pancreatic mucinous cysts were identified, including IPMN and mucinous cystic neoplasm (MCN). Immunohistochemical analysis of MSLN was performed on representative sections. Results: MSLN was seen more frequently in neoplastic epithelial cells from IPMN (39/52; P < .0005) and MCN (9/14; P < .0001) compared with unremarkable adjacent pancreatic and bile ducts (0/57) and benign foveolar and duodenal epithelium (0/21). When present, MSLN was diffusely expressed in neoplastic epithelium and only focally expressed in adjacent ducts (8/57). No significant difference was seen (P = .26) in MLSN expression between IPMN (79%) and MCN (83%) when only presence or absence was considered. Conclusion: Our findings suggest that MLSN can be used as a marker of neoplastic transformation of epithelial cells in pancreatic mucinous cysts. The findings can help identify neoplastic mucinous epithelium.

引用

页码：313 / 319

页数：7

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