In Vitro and In Vivo Antioxidant Activity of Agave sisalana Agro-Industrial Residue

被引:22
作者
Barreto, Stella Maria Andrade Gomes [1 ]
Cadavid, Cesar Orlando Munoz [1 ]
Moura, Rafael Amir de Oliveira [1 ]
Silva, Giovanna Melo Martins [1 ]
de Araujo, Samara Vitoria Ferreira [1 ]
da Silva Filho, Jean Antonio Aderaldo [1 ]
Rocha, Hugo Alexandre Oliveira [1 ]
Oliveira, Riva de Paula [1 ]
Giordani, Raquel Brandt [1 ]
Ferrari, Marcio [1 ]
机构
[1] Univ Fed Rio Grande do Norte, Coll Pharm, BR-59012570 Natal, RN, Brazil
关键词
Agave sisalana; agro-industrial; antioxidant; residue; ANTIPROLIFERATIVE ACTIVITIES; STRUCTURAL-CHARACTERIZATION; ANTIAGING ACTIVITIES; ASSISTED EXTRACTION; POLYSACCHARIDES; SAPONINS; ELUCIDATION; FLAVONOIDS; FEATURES; PRODUCT;
D O I
10.3390/biom10101435
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Agave sisalana agro-industrial residue has considerable potential against damage associated with oxidative stress and skin aging. This study aims to demonstrate, in vitro and in vivo, the potential of Agave sisalana agro-industrial residue as a safe and effective alternative for the prevention of damage caused by oxidative stress and aging. The antioxidant activity was evaluated in vitro (total antioxidant capacity, reducing power, DPPH radical scavenging, metal chelating (Fe2+ and Cu2+), and hydroxyl radical scavenging) and in vivo using the Caenorhabditis elegans organism model. The extract showed in vitro antioxidant activity in all tests performed. Tests with C. elegans showed that the extract was able to reduce the intracellular levels of reactive oxygen species (ROS) and increase the survival rate of worms. A downregulation of gst-4::GFP expression suggests a direct action against free radicals. Agave sisalana agro-industrial residue extract (AsRE) can therefore be considered as a source of antioxidant biomolecules, and the use of this agro-industrial residue in a new production process can lead to sustainability and socioeconomic development.
引用
收藏
页码:1 / 17
页数:17
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