A convenient palladium-catalyzed carbonylative synthesis of quinazolines from 2-aminobenzylamine and aryl bromides

被引：31

作者：

Chen, Jianbin ^{[1
]}

Natte, Kishore ^{[1
]}

Neumann, Helfried ^{[1
]}

Wu, Xiao-Feng ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse, D-18059 Rostock, Germany

来源：

RSC ADVANCES | 2014年 / 4卷 / 99期

关键词：

STOICHIOMETRIC CARBON-MONOXIDE; ONE-POT SYNTHESIS; O-PHENYL OXIMES; AEROBIC OXIDATION; CASCADE SYNTHESIS; DOMINO REACTIONS; DERIVATIVES; HETEROCYCLES; NUCLEOPHILES; INHIBITORS;

D O I：

10.1039/c4ra11303a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and practical strategy towards quinazoline scaffolds synthesis has been achieved. Through palladium-catalyzed carbonylative coupling of 2-aminobenzylamine with aryl bromides, the desired quinazolines were produced in moderate to good yields for the first time. The reactions followed an aminocarbonylation-condensation-oxidation sequence in a one-pot one-step manner. Preliminary investigation showed DMSO serves both as solvent and oxidant in this procedure.

引用

页码：56502 / 56505

页数：4

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