Cone Degeneration in Aging and Age-Related Macular Degeneration

被引:69
作者
Shelley, Elizabeth J. [1 ]
Madigan, Michele C. [3 ]
Natoli, Riccardo [1 ]
Penfold, Philip L. [1 ]
Provis, Jan M. [1 ,2 ]
机构
[1] Australian Natl Univ, Res Sch Biol Sci, Canberra, ACT 2601, Australia
[2] Australian Natl Univ, Sch Med, Canberra, ACT 2601, Australia
[3] Univ Sydney, Save Sight Inst, Sydney, NSW 2006, Australia
基金
澳大利亚研究理事会;
关键词
HUMAN RETINA; MULTIFOCAL ELECTRORETINOGRAM; VISUAL FUNCTION; PRIMATE RETINA; CELL-TYPES; MACULOPATHY; PHOTORECEPTORS; SENSITIVITY; DYSFUNCTION; PROGRESSION;
D O I
10.1001/archophthalmol.2008.622
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objective: To examine the morphological features of macular photoreceptors in histologically normal retina from normal donor eyes and eyes with age-related macular degeneration (AMD). Methods: The macular region was excised from 18 donor eyes (aged 22-96 years) and cryosectioned. Sections were stained with hematoxylin-eosin or double immunolabeled using opsin antibodies or synaptic markers. Results: Three of 8 retinas studied in detail had AMD lesions; the remainder were histologically normal. Immunoreactivity to cone opsin was abnormal in parts of all retinas (3.5%-95.0% of each sample) and was associated with swelling of and altered immunoreactivity in the mainly in nonfoveal macular locations. The nature of the anomalies was identical in non-AMD retinas and in parts of AMD retinas adjacent to overt degeneration. Conclusion: Redistribution of opsin and anomalies in the distal cone axon are common in the aging human macula and may indicate susceptibility to AMD. Clinical Relevance: The findings are consistent with tests of cone function in aging and early AMD, which suggests that integrated cone functions-including contrast sensitivity, color matching, and short wavelength-sensitive cone sensitivity-are the most reliable prognostic indicators of progression in AMD.
引用
收藏
页码:483 / 492
页数:10
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