Oral delivery of proteins and peptides by mucoadhesive nanoparticles

被引：27

作者：

Sharifi, Simin ^{[1
]}

Samani, Amir Abbas ^{[2
]}

Ahmadian, Elham ^{[1
]}

Eftekhari, Aziz ^{[3
]}

Derakhshankhah, Hossein ^{[4
]}

Jafari, Samira ^{[4
]}

Mokhtarpour, Masumeh ^{[5
]}

Vahed, Sepideh Zununi ^{[6
]}

Salatin, Sara ^{[7
,8
]}

Dizaj, Solmaz Maleki ^{[1
]}

机构：

[1] Tabriz Univ Med Sci, Dent & Periodontal Res Ctr, Tabriz, Iran

[2] William Osler Hlth Ctr, Brampton, ON, Canada

[3] Maragheh Univ Med Sci, Pharmacol & Toxicol Dept, Maragheh, Iran

[4] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah, Iran

[5] Univ Tabriz, Dept Phys Chem, Tabriz, Iran

[6] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran

[7] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[8] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

来源：

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2019年 / 9卷 / 02期

关键词：

Nanotechnology; Mucoadhesive nanoparticles; Oral delivery; COPOLYMERS;

D O I：

10.33263/BRIAC92.849852

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

It seems that an ever growing tendency is necessary for the development of a strategy that can not only protect the peptides and proteins from degradation by the enzymes but also can improve their absorption without affecting biological activity. Delivery of peptides and proteins into the oral cavity remains an interesting approach, however for its availability some distinctive problems should be addressed. A wide variety of carriers have been investigated for delivery of peptides and proteins for the protection of their formulation and structure against the enzymatic environment of the gastrointestinal tract.

引用

页码：3849 / 3852

页数：4

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