共 32 条
High-Fat Diet Induces Apoptosis of Hypothalamic Neurons
被引:305
作者:

Moraes, Juliana C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Coope, Andressa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Morari, Joseane
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Cintra, Dennys E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Roman, Erika A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Pauli, Jose R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Romanatto, Talita
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Carvalheira, Jose B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Oliveira, Alexandre L. R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Anat, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Saad, Mario J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Velloso, Licio A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
机构:
[1] Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
[2] Univ Estadual Campinas, Dept Anat, Campinas, SP, Brazil
来源:
PLOS ONE
|
2009年
/
4卷
/
04期
关键词:
D O I:
10.1371/journal.pone.0005045
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Consumption of dietary fats is amongst the most important environmental factors leading to obesity. In rodents, the consumption of fat-rich diets blunts leptin and insulin anorexigenic signaling in the hypothalamus by a mechanism dependent on the in situ activation of inflammation. Since inflammatory signal transduction can lead to the activation of apoptotic signaling pathways, we evaluated the effect of high-fat feeding on the induction of apoptosis of hypothalamic cells. Here, we show that consumption of dietary fats induce apoptosis of neurons and a reduction of synaptic inputs in the arcuate nucleus and lateral hypothalamus. This effect is dependent upon diet composition, and not on caloric intake, since pair-feeding is not sufficient to reduce the expression of apoptotic markers. The presence of an intact TLR4 receptor, protects cells from further apoptotic signals. In diet-induced inflammation of the hypothalamus, TLR4 exerts a dual function, on one side activating pro-inflammatory pathways that play a central role in the development of resistance to leptin and insulin, and on the other side restraining further damage by controlling the apoptotic activity.
引用
收藏
页数:11
相关论文
共 32 条
[1]
Pathogen recognition and innate immunity
[J].
Akira, S
;
Uematsu, S
;
Takeuchi, O
.
CELL,
2006, 124 (04)
:783-801

Akira, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Res Inst Microbial Dis, Dept Host Defense, Suita, Osaka 5650871, Japan

Uematsu, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Res Inst Microbial Dis, Dept Host Defense, Suita, Osaka 5650871, Japan

Takeuchi, O
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Res Inst Microbial Dis, Dept Host Defense, Suita, Osaka 5650871, Japan
[2]
Restoration of insulin secretion in pancreatic islets of protein-deficient rats by reduced expression of insulin receptor substrate (IRS)-1 and IRS-2
[J].
Araujo, EP
;
Amaral, MEC
;
Filiputti, E
;
de Souza, CT
;
Laurito, TL
;
Augusto, VD
;
Saad, MJA
;
Boschero, AC
;
Velloso, LA
;
Carneiro, EM
.
JOURNAL OF ENDOCRINOLOGY,
2004, 181 (01)
:25-38

Araujo, EP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil

Amaral, MEC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil

Filiputti, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil

de Souza, CT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil

Laurito, TL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil

Augusto, VD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil

Saad, MJA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil

Boschero, AC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil

Velloso, LA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil

Carneiro, EM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, UNICAMP, Dept Internal Med, FCM, BR-13083970 Campinas, SP, Brazil
[3]
The good and the bad news: surgery vs. drug therapy
[J].
Astrup, A.
.
OBESITY REVIEWS,
2008, 9 (01)
:1-3

Astrup, A.
论文数: 0 引用数: 0
h-index: 0
[4]
Neuronal PTP1B regulates body weight, adiposity and leptin action
[J].
Bence, Kendra K.
;
Delibegovic, Mirela
;
Xue, Bingzhong
;
Gorgun, Cem Z.
;
Hotamisligil, Gokhan S.
;
Neel, Benjamin G.
;
Kahn, Barbara B.
.
NATURE MEDICINE,
2006, 12 (08)
:917-924

Bence, Kendra K.
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

Delibegovic, Mirela
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

Xue, Bingzhong
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

Gorgun, Cem Z.
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

Hotamisligil, Gokhan S.
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

Neel, Benjamin G.
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

Kahn, Barbara B.
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA
[5]
Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight
[J].
Bertelli, Daniela F.
;
Araujo, Eliana P.
;
Cesquini, Maristela
;
Stoppa, Graziela R.
;
Gasparotto-Contessotto, Miriam
;
Toyama, Marcos H.
;
Felix, Jorge V. C.
;
Carvalheira, Jose B.
;
Michelini, Lisete C.
;
Chiavegatto, Silvana
;
Boschero, Antonio C.
;
Saad, Mario J. A.
;
Lopes-Cendes, Iscia
;
Velloso, Licio A.
.
ENDOCRINOLOGY,
2006, 147 (11)
:5385-5399

Bertelli, Daniela F.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Araujo, Eliana P.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Cesquini, Maristela
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Stoppa, Graziela R.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Gasparotto-Contessotto, Miriam
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Toyama, Marcos H.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Felix, Jorge V. C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Carvalheira, Jose B.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Michelini, Lisete C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Chiavegatto, Silvana
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Boschero, Antonio C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Saad, Mario J. A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Lopes-Cendes, Iscia
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Velloso, Licio A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil
[6]
Insulin modulates leptin-induced STAT3 activation in rat hypothalamus
[J].
Carvalheira, JBC
;
Siloto, RMP
;
Ignacchitti, I
;
Brenelli, SL
;
Carvalho, CRO
;
Leite, A
;
Velloso, LA
;
Gontijo, JAR
;
Saad, MJA
.
FEBS LETTERS,
2001, 500 (03)
:119-124

Carvalheira, JBC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, FCM, Dept Clin Med, BR-13081970 Campinas, SP, Brazil

Siloto, RMP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, FCM, Dept Clin Med, BR-13081970 Campinas, SP, Brazil

Ignacchitti, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, FCM, Dept Clin Med, BR-13081970 Campinas, SP, Brazil

Brenelli, SL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, FCM, Dept Clin Med, BR-13081970 Campinas, SP, Brazil

Carvalho, CRO
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, FCM, Dept Clin Med, BR-13081970 Campinas, SP, Brazil

Leite, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, FCM, Dept Clin Med, BR-13081970 Campinas, SP, Brazil

Velloso, LA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, FCM, Dept Clin Med, BR-13081970 Campinas, SP, Brazil

Gontijo, JAR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, FCM, Dept Clin Med, BR-13081970 Campinas, SP, Brazil

Saad, MJA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, FCM, Dept Clin Med, BR-13081970 Campinas, SP, Brazil
[7]
Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes -: Many differences, few similarities
[J].
Cnop, M
;
Welsh, N
;
Jonas, JC
;
Jörns, A
;
Lenzen, S
;
Eizirik, DL
.
DIABETES,
2005, 54
:S97-S107

Cnop, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Libre Bruxelles, Expt Med Lab, Fac Med, Erasmus Hosp, B-1070 Brussels, Belgium

Welsh, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Libre Bruxelles, Expt Med Lab, Fac Med, Erasmus Hosp, B-1070 Brussels, Belgium

Jonas, JC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Libre Bruxelles, Expt Med Lab, Fac Med, Erasmus Hosp, B-1070 Brussels, Belgium

Jörns, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Libre Bruxelles, Expt Med Lab, Fac Med, Erasmus Hosp, B-1070 Brussels, Belgium

Lenzen, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Libre Bruxelles, Expt Med Lab, Fac Med, Erasmus Hosp, B-1070 Brussels, Belgium

Eizirik, DL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Libre Bruxelles, Expt Med Lab, Fac Med, Erasmus Hosp, B-1070 Brussels, Belgium
[8]
Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action
[J].
De Souza, Claudio T.
;
Araujo, Eliana P.
;
Stoppiglia, Luiz F.
;
Pauli, Jose R.
;
Ropelle, Eduardo
;
Rocco, Silvana A.
;
Marin, Rodrigo M.
;
Franchini, Kleber G.
;
Carvalheira, Jose B.
;
Saad, Mario J.
;
Boschero, Antonio C.
;
Carneiro, Everardo M.
;
Velloso, Licio A.
.
FASEB JOURNAL,
2007, 21 (04)
:1153-1163

De Souza, Claudio T.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Araujo, Eliana P.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Stoppiglia, Luiz F.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Pauli, Jose R.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Ropelle, Eduardo
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Rocco, Silvana A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Marin, Rodrigo M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Franchini, Kleber G.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Carvalheira, Jose B.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Saad, Mario J.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Boschero, Antonio C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Carneiro, Everardo M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil

Velloso, Licio A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
[9]
Short-term inhibition of peroxisome proliferator-activated receptor-γ coactivator-1α expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice
[J].
De Souza, CT
;
Araújo, EP
;
Prada, PO
;
Saad, MJA
;
Boschero, AC
;
Velloso, LA
.
DIABETOLOGIA,
2005, 48 (09)
:1860-1871

De Souza, CT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Araújo, EP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Prada, PO
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Saad, MJA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Boschero, AC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083970 Campinas, SP, Brazil

Velloso, LA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083970 Campinas, SP, Brazil
[10]
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
[J].
De Souza, CT
;
Araujo, EP
;
Bordin, S
;
Ashimine, R
;
Zollner, RL
;
Boschero, AC
;
Saad, MJA
;
Velloso, LA
.
ENDOCRINOLOGY,
2005, 146 (10)
:4192-4199

De Souza, CT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083970 Campinas, SP, Brazil

Araujo, EP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083970 Campinas, SP, Brazil

Bordin, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083970 Campinas, SP, Brazil

Ashimine, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083970 Campinas, SP, Brazil

Zollner, RL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083970 Campinas, SP, Brazil

Boschero, AC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083970 Campinas, SP, Brazil

Saad, MJA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083970 Campinas, SP, Brazil

Velloso, LA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083970 Campinas, SP, Brazil