Consolidative thoracic radiotherapy for extensive stage small cell lung cancer

被引：12
|
作者：
Zhang, Xiaoli [1 ,2 ]
Yu, Jinming [1 ,2 ,3 ]
Zhu, Hui [2 ,3 ]
Meng, Xue [2 ,3 ]
Li, Minghuan [2 ,3 ]
Jiang, Liyang [2 ,3 ,4 ]
Ding, Xingchen [2 ,4 ]
Sun, Xindong [2 ,3 ]
机构：
[1] Renmin Hosp Wuhan Univ, Dept Oncol, Wuhan, Peoples R China
[2] Shandong Univ, Shandong Acad Med Sci, Shandong Canc Hosp Affiliated, Dept Radiat Oncol, Jinan, Shandong, Peoples R China
[3] Jinan Univ, Shandong Acad Med Sci, Jinan, Peoples R China
[4] Weifang Med Univ, Weifang, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 13期
关键词：
small cell lung cancer; extensive stage; thoracic radiotherapy; PHASE-III TRIAL; PROPHYLACTIC CRANIAL IRRADIATION; RANDOMIZED CONTROLLED-TRIAL; RADIATION-THERAPY; MAINTENANCE CHEMOTHERAPY; 1ST-LINE THERAPY; PLUS ETOPOSIDE; ONCOLOGY-GROUP; LOCAL-CONTROL; CARCINOMA;
D O I：
10.18632/oncotarget.14759
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Extensive stage small cell lung cancer (ES-SCLC) represents approximately half of all diagnosed small cell lung cancer worldwide. It is notorious for a high risk of local recurrence although it's sensitive to chemotherapy. Nearly 90% of intrathoracic failures happen in the first year after diagnosis. The cornerstone of treatment for ES-SCLC is etoposide-platinum based chemotherapy. Consolidative radiotherapy to thorax has diminished the incidence of local relapse, therefore it should be offered to patients with excellent response to induction first-line chemotherapy. This review centers on the clinical evidence for the use of thoracic radiotherapy (TRT) and current modalities of TRT delivery, then tries to determine a feasible way to conduct TRT in a selective group of cases.
引用
收藏
页码：22251 / 22261
页数：11
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