Palladium-Catalyzed Benzylic C-H Arylation of Azaarylmethylamines

被引：30

作者：

Kim, Byeong-Seon ^{[1
]}

Jimenez, Jacqueline ^{[1
,2
]}

Gao, Feng ^{[1
,3
]}

Wash, Patrick J. ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

[2] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Puebla 72570, Mexico

[3] Sichuan Agr Univ, Dept Med Plants, Agron Coll, Chengdu 611130, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 23期

关键词：

DIRECT ALPHA-ARYLATION; SITE-SELECTIVE SP(2); REGIOSELECTIVE ARYLATION; C(SP(3))-H ARYLATION; CROSS-COUPLINGS; ARYL HALIDES; PYRIDINES; POTENT; BOND; DERIVATIVES;

D O I：

10.1021/acs.orglett.5b02898

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct C-H functionalization approach to produce aryl(azaaryl)methylamines from azaarylmethylamines without directing groups is described. Under conditions where the azaarylmethylamines' C-H is reversibly deprotonated, a Pd(OAc)(2)/NIXANTPHOS-based catalyst couples the resulting carbanions with various aryl halides to provide aryl-(azaaryl)methylamines This umpolung strategy directly provides tertiary amines without protecting or activating groups.

引用

页码：5788 / 5791

页数：4

共 58 条

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