Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000-2016 in the Stockholm region and Sweden

被引：60

作者：

Haeggblom, Linnea ^{[1
]}

Attoff, Tove ^{[1
]}

Yu, Jingru ^{[2
]}

Holzhauser, Stefan ^{[1
]}

Vlastos, Andrea ^{[1
]}

Mirzae, Leila ^{[1
]}

Ahrlund-Richter, Andreas ^{[1
]}

Munck-Wikland, Eva ^{[3
]}

Marklund, Linda ^{[3
]}

Hammarstedt-Nordenvall, Lalle ^{[3
]}

Ye, Weimin ^{[2
]}

Ramqvist, Torbjorn ^{[1
]}

Nasman, Anders ^{[1
,4
]}

Dalianis, Tina ^{[1
]}

机构：

[1] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden

[2] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[3] Karolinska Inst, CLINTEC, Stockholm, Sweden

[4] Karolinska Univ Hosp, Dept Clin Pathol, Stockholm, Sweden

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 06期

关键词：

base of tongue cancer; human papillomavirus; incidence; oropharyngeal cancer; prevalence; tonsillar cancer; ORAL HUMAN-PAPILLOMAVIRUS; FAVORABLE PROGNOSTIC-FACTOR; SQUAMOUS-CELL CARCINOMAS; OROPHARYNGEAL CANCER; POSITIVE TONSILLAR; NECK-CANCER; INCIDENCE RATES; HPV; EXPRESSION; HEAD;

D O I：

10.1002/hed.25585

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background Tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) has increased. In Stockholm, the proportion of human papillomavirus (HPV)-positive cases and the incidence of TSCC rose between 1970 and 2006 then stabilized. Here, HPV-prevalence, and TSCC/BOTSCC incidence 2000-2016, in Stockholm and Sweden were followed. Methods Incidence data for 2000-2016 were obtained from the Swedish Cancer Registry. TSCC/BOTSCC biopsies, 2013-2016 from Stockholm, were examined for HPV DNA and p16(INK4a), or data obtained from medical reports. For cases 2000-2012, data were available from previous studies. Results The incidence of TSCC/BOTSCC has continued to rise in Stockholm and Sweden 2000-2016, especially after 2008. HPV DNA and p16(INK4a) analysis was determined for 795 Stockholm cases from 2000 to 2016, with 72% being HPV DNA and p16(INK4a) positive 2013-2016, and 70% positive 2000-2016. Conclusion During 2000-2016, especially after 2008, the incidence of TSCC/BOTSCC has continued to increase in Stockholm and Sweden, with an HPV-prevalence of approximately 70% in Stockholm.

引用

页码：1583 / 1590

页数：8

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