Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000-2016 in the Stockholm region and Sweden

被引：56

作者：

Haeggblom, Linnea ^{[1
]}

Attoff, Tove ^{[1
]}

Yu, Jingru ^{[2
]}

Holzhauser, Stefan ^{[1
]}

Vlastos, Andrea ^{[1
]}

Mirzae, Leila ^{[1
]}

Ahrlund-Richter, Andreas ^{[1
]}

Munck-Wikland, Eva ^{[3
]}

Marklund, Linda ^{[3
]}

Hammarstedt-Nordenvall, Lalle ^{[3
]}

Ye, Weimin ^{[2
]}

Ramqvist, Torbjorn ^{[1
]}

Nasman, Anders ^{[1
,4
]}

Dalianis, Tina ^{[1
]}

机构：

[1] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden

[2] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[3] Karolinska Inst, CLINTEC, Stockholm, Sweden

[4] Karolinska Univ Hosp, Dept Clin Pathol, Stockholm, Sweden

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 06期

关键词：

base of tongue cancer; human papillomavirus; incidence; oropharyngeal cancer; prevalence; tonsillar cancer; ORAL HUMAN-PAPILLOMAVIRUS; FAVORABLE PROGNOSTIC-FACTOR; SQUAMOUS-CELL CARCINOMAS; OROPHARYNGEAL CANCER; POSITIVE TONSILLAR; NECK-CANCER; INCIDENCE RATES; HPV; EXPRESSION; HEAD;

D O I：

10.1002/hed.25585

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background Tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) has increased. In Stockholm, the proportion of human papillomavirus (HPV)-positive cases and the incidence of TSCC rose between 1970 and 2006 then stabilized. Here, HPV-prevalence, and TSCC/BOTSCC incidence 2000-2016, in Stockholm and Sweden were followed. Methods Incidence data for 2000-2016 were obtained from the Swedish Cancer Registry. TSCC/BOTSCC biopsies, 2013-2016 from Stockholm, were examined for HPV DNA and p16(INK4a), or data obtained from medical reports. For cases 2000-2012, data were available from previous studies. Results The incidence of TSCC/BOTSCC has continued to rise in Stockholm and Sweden 2000-2016, especially after 2008. HPV DNA and p16(INK4a) analysis was determined for 795 Stockholm cases from 2000 to 2016, with 72% being HPV DNA and p16(INK4a) positive 2013-2016, and 70% positive 2000-2016. Conclusion During 2000-2016, especially after 2008, the incidence of TSCC/BOTSCC has continued to increase in Stockholm and Sweden, with an HPV-prevalence of approximately 70% in Stockholm.

引用

页码：1583 / 1590

页数：8

共 14 条

[1] Human Papillomavirus and Tonsillar and Base of Tongue Cancer
Ramqvist, Torbjorn
Grun, Nathalie
Dalianis, Tina
VIRUSES-BASEL, 2015, 7 (03): : 1332 - 1343
[2] The role of human papillomavirus in the increased incidence of base of tongue cancer
Attner, Per
Du, Juan
Nasman, Anders
Hammarstedt, Lalle
Ramqvist, Torbjorn
Lindholm, Johan
Marklund, Linda
Dalianis, Tina
Munck-Wikland, Eva
INTERNATIONAL JOURNAL OF CANCER, 2010, 126 (12) : 2879 - 2884
[3] Incidence of human papillomavirus positive tonsillar and base of tongue carcinoma: A stabilisation of an epidemic of viral induced carcinoma?
Nasman, Anders
Nordfors, Cecilia
Holzhauser, Stefan
Vlastos, Andrea
Tertipis, Nikolaos
Hammar, Ulf
Hammarstedt-Nordenvall, Lalle
Marklund, Linda
Munck-Wikland, Eva
Ramqvist, Torbjorn
Bottai, Matteo
Dalianis, Tina
EUROPEAN JOURNAL OF CANCER, 2015, 51 (01) : 55 - 61
[4] Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome
Ramqvist, Torbjorn
Nasman, Anders
Franzen, Bo
Bersani, Cinzia
Alexeyenko, Andrey
Becker, Susanne
Haeggblom, Linnea
Kolev, Aeneas
Dalianis, Tina
Munck-Wikland, Eva
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (04)
[5] Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral-induced carcinoma?
Nasman, Anders
Attner, Per
Hammarstedt, Lalle
Do, Juan
Eriksson, Mathilda
Giraud, Geraldine
Ahrlund-Richter, Sofie
Marklund, Linda
Romanitan, Mircea
Lindquist, David
Ramqvist, Torbjorn
Lindholm, Johan
Sparen, Par
Ye, Weimin
Dahistrand, Hanna
Munck-Wikland, Eva
Dalianis, Tina
INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (02) : 362 - 366
[6] A model for predicting clinical outcome in patients with human papillomavirus-positive tonsillar and base of tongue cancer
Tertipis, Nikolaos
Hammar, Ulf
Nasman, Anders
Vlastos, Andrea
Nordfors, Cecilia
Grun, Nathalie
Ahrlund-Richter, Andreas
Sivars, Lars
Haeggblom, Linnea
Marklund, Linda
Hammarstedt-Nordenvall, Lalle
Chaturvedi, Anil K.
Munck-Wikland, Eva
Ramqvist, Torbjorn
Bottai, Matteo
Dalianis, Tina
EUROPEAN JOURNAL OF CANCER, 2015, 51 (12) : 1580 - 1587
[7] HLA-A*02 in Relation to Outcome in Human Papillomavirus Positive Tonsillar and Base of Tongue Cancer
Tertipis, Nikolaos
Villabona, Lisa
Nordfors, Cecilia
Nasman, Anders
Ramqvist, Torbjorn
Vlastos, Andrea
Masucci, Giuseppe
Dalianis, Tina
ANTICANCER RESEARCH, 2014, 34 (05) : 2369 - 2375
[8] In vitro antitumor effects of FGFR and PI3K inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer cell lines
Holzhauser, Stefan
Kostopoulou, Ourania N.
Ohmayer, Anna
Lange, Birthe K. A.
Ramqvist, Torbjoern
Andonova, Teodora
Bersani, Cinzia
Wickstrom, Malin
Dalianis, Tina
ONCOLOGY LETTERS, 2019, 18 (06) : 6249 - 6260
[9] Targeted sequencing of tonsillar and base of tongue cancer and human papillomavirus positive unknown primary of the head and neck reveals prognostic effects of mutated FGFR3
Bersani, Cinzia
Sivars, Lars
Haeggblom, Linnea
DiLorenzo, Sebastian
Mints, Michael
Ahrlund-Richter, Andreas
Tertipis, Nikolaos
Munck-Wikland, Eva
Nasman, Anders
Ramqvist, Torbjorn
Dalianis, Tina
ONCOTARGET, 2017, 8 (21) : 35339 - 35350
[10] Studies on human papillomavirus (HPV) 16 E2, E5 and E7 mRNA in HPV-positive tonsillar and base of tongue cancer in relation to clinical outcome and immunological parameters
Ramqvist, Torbjorn
Mints, Michael
Tertipis, Nikolaos
Nasman, Anders
Romanitan, Mircea
Dalianis, Tina
ORAL ONCOLOGY, 2015, 51 (12) : 1126 - 1131

← 1 2 →