Structures and recognition modes of toll-like receptors

被引：52

作者：

Gao, Dong ^{[1
]}

Li, Wang ^{[1
]}

机构：

[1] Shenzhen Hornetcorn Biotechnol Co Ltd, Shenzhen 518045, Peoples R China

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2017年 / 85卷 / 01期

基金：

中国博士后科学基金;

关键词：

crystallographic structure; innate immunity; ligand; toll-like receptor; LEUCINE-RICH REPEAT; CRYSTAL-STRUCTURE; ENDOTOXIN ANTAGONIST; TLR4-MD-2; COMPLEX; LIGAND COMPLEXES; STRANDED-RNA; LIPOPOLYSACCHARIDE; BACTERIAL; BIOLOGY; DOMAIN;

D O I：

10.1002/prot.25179

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toll-like receptors (TLRs) recognize common structural patterns in diverse microbial molecules and play central roles in the innate immune response. The structures of extracellular domains and their ligand complexes of several TLRs have been determined by X-ray crystallography. Here, we discuss recent advances on structures and activation mechanisms of TLRs. Despite the differences in interaction areas of ligand with TLRs, the extracellular domains of TLRs all adopt horseshoe-shaped structures and the overall M-shape of the TLR-ligand complexes is strikingly similar. The structural rearrangement information of TLRs sheds new light on their ligand-recognition and -activation mechanisms. Proteins 2016; 85:3-9. (c) 2016 Wiley Periodicals, Inc.

引用

页码：3 / 9

页数：7

共 42 条

[1] Toll-like receptor signalling [J].

Akira, S ;

Takeda, K .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511

[2] Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition [J].

Bauer, S ;

Kirschning, CJ ;

Häcker, H ;

Redecke, V ;

Hausmann, S ;

Akira, S ;

Wagner, H ;

Lipford, GB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) :9237-9242

[3] The molecular structure of the Toll-like receptor 3 ligand-binding domain [J].

Bell, JK ;

Botos, I ;

Hall, PR ;

Askins, J ;

Shiloach, J ;

Segal, DM ;

Davies, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (31) :10976-10980

[4] The Structural Biology of Toll-like Receptors [J].

Botos, Istvan ;

Segal, David M. ;

Davies, David R. .

STRUCTURE, 2011, 19 (04) :447-459

[5] Two modes of ligand recognition by TLRs [J].

Brodsky, Igor ;

Medzhitov, Ruslan .

CELL, 2007, 130 (06) :979-981

[6]

Choe J, 2005, SCIENCE, V309, P581, DOI 10.1126/science.1115253

[7] Structure and function of lipopolysaccharides [J].

Erridge, C ;

Bennett-Guerrero, E ;

Poxton, IR .

MICROBES AND INFECTION, 2002, 4 (08) :837-851

[8] Structure and function of toll receptors and their Ligands [J].

Gay, Nicholas J. ;

Gangloff, Monique .

ANNUAL REVIEW OF BIOCHEMISTRY, 2007, 76 :141-165

[9] Structures of TLR-ligand complexes [J].

Jin, Mi Sun ;

Lee, Jie-Oh .

CURRENT OPINION IN IMMUNOLOGY, 2008, 20 (04) :414-419

[10] Structures of the toll-like receptor family and its ligand complexes [J].

Jin, Mi Sun ;

Lee, Jie-Oh .

IMMUNITY, 2008, 29 (02) :182-191

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