Requirements for effective IgE cross-linking on mast cells and basophils

被引：71
|
作者：
Knol, Edward F. [1 ]
机构：
[1] Univ Utrecht, Med Ctr, Dept Dermatol Allergol, NL-3508 TA Utrecht, Netherlands
来源：
MOLECULAR NUTRITION & FOOD RESEARCH | 2006年 / 50卷 / 07期
关键词：
allergen; cytokines; degranulation; histamine;
D O I：
10.1002/mnfr.200500272
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
This article reviews the characteristics of high affinity IgE receptors (Fc epsilon RI) and their role in the response to allergenic proteins. The requirements for successful cross-linking of Fc epsilon RI on basophils and mast cells and subsequent degranulation by allergenic proteins will be explained in detail. Methods for in vitro analysis of allergen-induced mast cell and basophil degranulation will be described and issues/problems in applying these methods will be discussed. Finally, implications for manipulation of protein allergens will be discussed.
引用
收藏
页码：620 / 624
页数：5
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