Gut microbiota: A player in aging and a target for anti-aging intervention

被引：332
作者：
Vaiserman, Alexander M. [1 ]
Koliada, Alexander K. [1 ]
Marotta, Francesco [2 ,3 ]
机构：
[1] NAMS, DF Chebotarev Inst Gerontol, Kiev, Ukraine
[2] ReGenera Res Grp Aging Intervent, Milan, Italy
[3] Montenapoleone Clin, Hlth Aging Unit, Milan, Italy
来源：
AGEING RESEARCH REVIEWS | 2017年 / 35卷
关键词：
Gut microbiota; Probiotic; Aging; Age-related disease; Lifespan; Healthspan; CLOSTRIDIUM-DIFFICILE INFECTION; HUMAN INTESTINAL MICROBIOTA; LACTOBACILLUS-PLANTARUM HY7714; FECAL MICROBIOTA; CAENORHABDITIS-ELEGANS; PARKINSONS-DISEASE; INSULIN-RESISTANCE; PHYLOGENETIC MICROARRAY; DIABETES-MELLITUS; FROZEN INOCULUM;
D O I：
10.1016/j.arr.2017.01.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aging-associated alterations in composition, diversity and functional features of intestinal microbiota are well-described in the modern literature. They are suggested to be caused by an age-related decline in immune system functioning (immunosenescence) and a low-grade chronic inflammation (inflammaging), which accompany many aging-associated pathologies. The microbiota-targeted dietary and probiotic interventions have been shown to favorably affect the host health and aging by an enhancement of antioxidant activity, improving immune homeostasis, suppression of chronic inflammation, regulation of fat deposition and metabolism and prevention of insulin resistance. Recently, a high effectiveness and safety of novel therapeutic application such as fecal microbiota transplantation in the prevention and treatment of age-related pathological conditions including atherosclerosis, type 2 diabetes and Parkinson's disease has been demonstrated. In this review, recent research findings are summarized on the role of gut micribiota in aging processes with emphasis on therapeutic potential of microbiome-targeted interventions in anti-aging medicine. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：36 / 45
页数：10
相关论文
共 128 条
[1]  
Ananthaswamy A., 2011, NEW SCI, V209, P8, DOI [10.1016/S0262-4079(11)60124-3, DOI 10.1016/S0262-4079(11)60124-3]
[2]  
[Anonymous], MOL NUTR FOOD RES
[3]   Gut Bifidobacteria Populations in Human Health and Aging [J].
Arboleya, Silvia ;
Watkins, Claire ;
Stanton, Catherine ;
Ross, R. Paul .
FRONTIERS IN MICROBIOLOGY, 2016, 7
[4]   Gut Microbiota and Extreme Longevity [J].
Biagi, Elena ;
Franceschi, Claudio ;
Rampelli, Simone ;
Severgnini, Marco ;
Ostan, Rita ;
Turroni, Silvia ;
Consolandi, Clarissa ;
Quercia, Sara ;
Scurti, Maria ;
Monti, Daniela ;
Capri, Miriam ;
Brigidi, Patrizia ;
Candela, Marco .
CURRENT BIOLOGY, 2016, 26 (11) :1480-1485
[5]   Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians [J].
Biagi, Elena ;
Nylund, Lotta ;
Candela, Marco ;
Ostan, Rita ;
Bucci, Laura ;
Pini, Elisa ;
Nikkila, Janne ;
Monti, Daniela ;
Satokari, Reetta ;
Franceschi, Claudio ;
Brigidi, Patrizia ;
De Vos, Willem .
PLOS ONE, 2010, 5 (05)
[6]   Microbiota and aging [J].
Bischoff, Stephan C. .
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2016, 19 (01) :26-30
[7]   Probiotic use in clinical practice: what are the risks? [J].
Boyle, Robert J. ;
Robins-Browne, Roy M. ;
Tang, Mimi L. K. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 83 (06) :1256-1264
[8]   Maintenance of a healthy trajectory of the intestinal microbiome during aging: A dietary approach [J].
Candela, Marco ;
Biagi, Elena ;
Brigidi, Patrizia ;
O'Toole, Paul W. ;
De Vos, Willem M. .
MECHANISMS OF AGEING AND DEVELOPMENT, 2014, 136 :70-75
[9]   Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly [J].
Cattaneo, Annamaria ;
Cattane, Nadia ;
Galluzzi, Samantha ;
Provasi, Stefania ;
Lopizzo, Nicola ;
Festari, Cristina ;
Ferrari, Clarissa ;
Guerra, Ugo Paolo ;
Paghera, Barbara ;
Muscio, Cristina ;
Bianchetti, Angelo ;
Volta, Giorgio Dalla ;
Turla, Marinella ;
Cotelli, Maria Sofia ;
Gennuso, Michele ;
Prelle, Alessandro ;
Zanetti, Orazio ;
Lussignoli, Giulia ;
Mirabile, Dario ;
Bellandi, Daniele ;
Gentile, Simona ;
Belotti, Gloria ;
Villani, Daniele ;
Harach, Taoufiq ;
Bolmont, Tristan ;
Padovani, Alessandro ;
Boccardi, Marina ;
Frisoni, Giovanni B. .
NEUROBIOLOGY OF AGING, 2017, 49 :60-68
[10]   Gut Microbiota Modification: Another Piece in the Puzzle of the Benefits of Physical Exercise in Health? [J].
Cerda, Begona ;
Perez, Margarita ;
Perez-Santiago, Jennifer D. ;
Tornero-Aguilera, Jose F. ;
Gonzalez-Soltero, Rocio ;
Larrosa, Mar .
FRONTIERS IN PHYSIOLOGY, 2016, 7
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