Antimicrobial Susceptibility Patterns in Outpatient Urinary Tract Infection in the District of Coimbra, Portugal: A Cross-Sectional Study
被引:3
作者:
Curto, Carolina
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机构:
Univ Coimbra, Fac Med, Coimbra, PortugalUniv Coimbra, Fac Med, Coimbra, Portugal
Curto, Carolina
[1
]
Rosendo, Ines
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机构:
Univ Coimbra, Fac Med, Coimbra, Portugal
Unidade Saude Familiar Coimbra Ctr, Coimbra, PortugalUniv Coimbra, Fac Med, Coimbra, Portugal
Rosendo, Ines
[1
,2
]
Santiago, Luiz
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机构:
Univ Coimbra, Fac Med, Coimbra, Portugal
Unidade Saude Familiar Topazio, Coimbra, Portugal
Adm Reg Saude Ctr, Coimbra, PortugalUniv Coimbra, Fac Med, Coimbra, Portugal
Santiago, Luiz
[1
,3
,4
]
机构:
[1] Univ Coimbra, Fac Med, Coimbra, Portugal
[2] Unidade Saude Familiar Coimbra Ctr, Coimbra, Portugal
[3] Unidade Saude Familiar Topazio, Coimbra, Portugal
Introduction: Urinary tract infections in the community setting are quite common. It is necessary to be aware of antibiotic susceptibility patterns in order to provide rational empirical therapy. The aim of this study is to determine the frequency and antimicrobial susceptibility of the strains responsible for urinary tract infections in primary health care, in the district of Coimbra, Portugal. Material and Methods: In this observational and cross-sectional study, we analyzed 7134 positive urine cultures of outpatient laboratories in the district of Coimbra, over one year. In most cases, a positive culture was defined by a threshold of 10(5) colony-forming units per milliliter and was conducted by the automated system VITEK (R) 2, by bioMerieux. We used descriptive and inferential statistics to determine the prevalence and antimicrobial susceptibility of bacteria and to ascertain whether there were differences associated with sex and age. Results: From the total of positive cultures, 83.4% pertained to females and 41.0% to individuals over 75 years old. Escherichia coli was the most frequent strain (63.9%), although its prevalence was lower (p < 0.001) in males and individuals over 75 years old. Its susceptibility to fosfomycin and nitrofurantoin was higher than 95% and with ciprofloxacin and trimethoprim/sulfamethoxazole it was lower than 80%. Resistances were more frequent (p < 0.001) in males and in the elderly. Discussion: Escherichia coli was the most frequent strain, revealing less resistance to fosfomycin and nitrofurantoin. Antimicrobial susceptibility was lower in the elderly and in males, populations in whom empirical therapy may be less successful. Conclusion: In order to improve clinical results, we recommend periodic surveillance of antimicrobial susceptibility, which could enable the provision of efficient information to clinicians, namely those who prescribe empirically for such infections, as well as standardization of identification methods of bacterial strains diagnosis and of the antibiotic kits to be tested.
机构:
Guys & St Thomas NHS Trust, St Thomas Hosp, Dept Infect, London SE1 7EH, England
Kings Coll London, St Thomas Hosp, Ctr Clin Infect & Diagnost Res, London, EnglandGuys & St Thomas NHS Trust, St Thomas Hosp, Dept Infect, London SE1 7EH, England
Aryee, Anna
Price, Nicholas
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Guys & St Thomas NHS Trust, St Thomas Hosp, Dept Infect, London SE1 7EH, EnglandGuys & St Thomas NHS Trust, St Thomas Hosp, Dept Infect, London SE1 7EH, England
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Publ Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, EnglandPubl Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, England
Chin, Teh Li
McNulty, Cliodna
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Gloucestershire Royal Hosp, Publ Hlth England Natl Infect Serv, Primary Care Unit, Microbiol Lab, Great Western Rd, Gloucester GL1 3NN, EnglandPubl Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, England
McNulty, Cliodna
Beck, Charles
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Publ Hlth England Natl Infect Serv, Field Epidemiol Serv South West, 2 Rivergate, Bristol BS1 6EH, Avon, EnglandPubl Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, England
Beck, Charles
MacGowan, Alasdair
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Publ Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, EnglandPubl Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, England
机构:
Winthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Cunha, B. A.
Cunha, C. B.
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Rhode Isl Hosp, Div Infect Dis, Providence, RI USA
Miriam Hosp, Providence, RI 02906 USA
Brown Univ, Alpert Sch Med, Providence, RI 02912 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Cunha, C. B.
Lam, B.
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机构:
Winthrop Univ Hosp, Dept Pharm, Mineola, NY 11501 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Lam, B.
Giuga, J.
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Winthrop Univ Hosp, Dept Pharm, Mineola, NY 11501 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Giuga, J.
Chin, J.
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Winthrop Univ Hosp, Dept Pharm, Mineola, NY 11501 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Chin, J.
Zafonte, V. F.
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Winthrop Univ Hosp, Dept Pharm, Mineola, NY 11501 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Zafonte, V. F.
Gerson, S.
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机构:
Winthrop Univ Hosp, Dept Pharm, Mineola, NY 11501 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
机构:
Guys & St Thomas NHS Trust, St Thomas Hosp, Dept Infect, London SE1 7EH, England
Kings Coll London, St Thomas Hosp, Ctr Clin Infect & Diagnost Res, London, EnglandGuys & St Thomas NHS Trust, St Thomas Hosp, Dept Infect, London SE1 7EH, England
Aryee, Anna
Price, Nicholas
论文数: 0引用数: 0
h-index: 0
机构:
Guys & St Thomas NHS Trust, St Thomas Hosp, Dept Infect, London SE1 7EH, EnglandGuys & St Thomas NHS Trust, St Thomas Hosp, Dept Infect, London SE1 7EH, England
机构:
Publ Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, EnglandPubl Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, England
Chin, Teh Li
McNulty, Cliodna
论文数: 0引用数: 0
h-index: 0
机构:
Gloucestershire Royal Hosp, Publ Hlth England Natl Infect Serv, Primary Care Unit, Microbiol Lab, Great Western Rd, Gloucester GL1 3NN, EnglandPubl Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, England
McNulty, Cliodna
Beck, Charles
论文数: 0引用数: 0
h-index: 0
机构:
Publ Hlth England Natl Infect Serv, Field Epidemiol Serv South West, 2 Rivergate, Bristol BS1 6EH, Avon, EnglandPubl Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, England
Beck, Charles
MacGowan, Alasdair
论文数: 0引用数: 0
h-index: 0
机构:
Publ Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, EnglandPubl Hlth England Natl Infect Serv, Specialist Microbiol Serv South West, Dept Infect Sci, Bristol BS10 5NB, Avon, England
机构:
Winthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Cunha, B. A.
Cunha, C. B.
论文数: 0引用数: 0
h-index: 0
机构:
Rhode Isl Hosp, Div Infect Dis, Providence, RI USA
Miriam Hosp, Providence, RI 02906 USA
Brown Univ, Alpert Sch Med, Providence, RI 02912 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Cunha, C. B.
Lam, B.
论文数: 0引用数: 0
h-index: 0
机构:
Winthrop Univ Hosp, Dept Pharm, Mineola, NY 11501 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Lam, B.
Giuga, J.
论文数: 0引用数: 0
h-index: 0
机构:
Winthrop Univ Hosp, Dept Pharm, Mineola, NY 11501 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Giuga, J.
Chin, J.
论文数: 0引用数: 0
h-index: 0
机构:
Winthrop Univ Hosp, Dept Pharm, Mineola, NY 11501 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Chin, J.
Zafonte, V. F.
论文数: 0引用数: 0
h-index: 0
机构:
Winthrop Univ Hosp, Dept Pharm, Mineola, NY 11501 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA
Zafonte, V. F.
Gerson, S.
论文数: 0引用数: 0
h-index: 0
机构:
Winthrop Univ Hosp, Dept Pharm, Mineola, NY 11501 USAWinthrop Univ Hosp, Div Infect Dis, 222 Stn Plaza North,Suite 432, Mineola, NY 11501 USA