Therapeutic potential of granulocyte microvesicles in sepsis

被引：1
|
作者：
Mackman, Nigel [1 ,2 ]
Hisada, Yohei [1 ,2 ]
机构：
[1] Univ N Carolina, Chapel Hill, NC 27515 USA
[2] UNC, Ctr Blood Res, Chapel Hill, NC 27515 USA
来源：
BLOOD | 2022年 / 139卷 / 15期
关键词：
PLASMINOGEN-ACTIVATOR; MICROPARTICLES;
D O I：
10.1182/blood.2021015280
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The study by Cointe et al(1) in this issue of Blood shows that microvesicles (MVs) from human granulocytes express urokinase plasminogen activator receptor (uPAR) and when loaded with urokinase (uPA) lyse clots in vitro and reduce microthrombi in kidneys and lungs of septic mice and increase their survival. In addition, neutrophil elastase (NE) increased fibrinolysis by degrading plasminogen activator inhibitor 1 (PAI-1).
引用
收藏
页码：2269 / 2271
页数：4
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