The role of CpG motifs in innate immunity

被引：304

作者：

Krieg, AM ^{[1
]}

机构：

[1] Univ Iowa, Coll Med, Dept Vet Affairs Med Ctr, Dept Internal Med, Iowa City, IA 52242 USA

[2] CpG ImmunoPharmaceut, Wellesley, MA 02481 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0952-7915(99)00048-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pattern recognition receptors of the innate immune system are able to distinguish certain prokaryotic DNAs from vertebrate DNAs by detecting unmethylated CpG dinucleotides in particular base contexts ('CpG motifs'). Recent studies have begun to define the molecular mechanisms of actions of CpG motifs and have demonstrated their stimulatory effects on leukocytes from humans and vertebrates other than mice. Oligodeoxynucleotides containing CpG motifs are highly effective Th1-like vaccine adjuvants through multiple routes of immunization and show promise as immunotherapeutic agents for cancer and allergic diseases.

引用

页码：35 / 43

页数：9

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