DETECTION OF INCREASED VASCULAR SIGNAL IN ARTHRITIS-PRONE RATS WITHOUT JOINT SWELLING USING SUPERB MICROVASCULAR IMAGING ULTRASONOGRAPHY

被引：6

作者：

Horie, Tatsunori ^{[1
,2
]}

Nishida, Mutsumi ^{[1
,3
]}

Tanimura, Shun ^{[4
,5
]}

Kamishima, Tamotsu ^{[6
]}

Tamai, Erika ^{[6
,9
]}

Morimura, Yutaka ^{[7
]}

Nishibata, Yuka ^{[7
]}

Masuda, Sakiko ^{[7
]}

Nakazawa, Daigo ^{[4
,5
]}

Tomaru, Utaano ^{[5
,8
]}

Atsumi, Tatsuya ^{[4
,5
]}

Ishizu, Akihiro ^{[7
]}

机构：

[1] Hokkaido Univ Hosp, Diagnost Ctr Sonog, Kita Ku, Sapporo, Hokkaido, Japan

[2] Hokkaido Univ Hosp, Dept Radiol Technol, Kita Ku, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ Hosp, Div Lab & Transfus Med, Kita Ku, Sapporo, Hokkaido, Japan

[4] Hokkaido Univ, Fac Med, Dept Rheumatol Endocrinol & Nephrol, Kita Ku, Sapporo, Hokkaido, Japan

[5] Hokkaido Univ, Grad Sch Med, Kita Ku, Sapporo, Hokkaido, Japan

[6] Hokkaido Univ, Fac Hlth Sci, Dept Biomed Sci & Engn, Kita Ku, Sapporo, Hokkaido, Japan

[7] Hokkaido Univ, Fac Hlth Sci, Dept Med Lab Sci, Kita Ku, N-12,W-5, Sapporo, Hokkaido 0600812, Japan

[8] Hokkaido Univ, Fac Med, Dept Pathol, Kita Ku, Sapporo, Hokkaido, Japan

[9] Hiroshima Prefectural Hosp, Dept Radiol, Minami Ku, 1-5-54 Ujinakanda, Hiroshima 7348530, Japan

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2019年 / 45卷 / 08期

关键词：

Animal model; Power Doppler; Rheumatoid arthritis; Superb microvascular imaging; Synovitis; Ultrasound; RHEUMATOID-ARTHRITIS; RHEUMATOLOGY/EUROPEAN LEAGUE; CLASSIFICATION CRITERIA; DOPPLER ULTRASONOGRAPHY; SYNOVIAL VASCULARITY; CLINICAL REMISSION; AMERICAN-COLLEGE; FINGER JOINTS; ULTRASOUND; PANNUS;

D O I：

10.1016/j.ultrasmedbio.2019.04.002

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

This study aimed to determine whether ultrasonography (US) can detect increased vascular signal in the synovial tissue before overt synovitis in rheumatoid arthritis (RA). Env-pX rats that spontaneously develop RA-like synovitis were used. Ankle joints of 15 pre-morbid env-pX rats were observed with power Doppler and superb microvascular imaging (SMI) using an ultrahigh-frequency (8-24 MHz) probe. Signal values were counted as the number of pixels. The total number of vessels and vessel area in the synovial tissue were histologically evaluated. Dilated vessels were determined from the mean value of synovial vessels in three wild-type rats. In all env-pX rats, apparent synovial proliferation was not observed. However, vasodilation was evident. Only SMI values were significantly correlated with the number of dilated vessels (r = 0.585, p = 0.022) but not with the total number of vessels. US with SMI using ultrahigh-frequency probe can detect increased vascular signal in the synovial tissue of arthritis-prone rats. (C) 2019 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

引用

页码：2086 / 2093

页数：8

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