Pd(II)-Catalyzed arylation of unactivated methylene C(sp3)-H bonds with aryl halides using a removable auxiliary

被引：81

作者：

Zhang, Qi ^{[1
]}

Yin, Xue-Song ^{[1
]}

Zhao, Sheng ^{[1
]}

Fang, Sheng-Long ^{[1
]}

Shi, Bing-Feng ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 61期

基金：

美国国家科学基金会;

关键词：

C-H BONDS; CATALYZED DIRECT ARYLATION; CARBON-HYDROGEN BONDS; COUPLING REACTIONS; DIRECTING GROUP; BETA-LACTAMS; PALLADIUM; FUNCTIONALIZATION; ACTIVATION; ALKYLATION;

D O I：

10.1039/c4cc03615h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Pd(II)-catalyzed arylation of methylene C(sp(3))-H bonds in aliphatic amides directed by our newly developed PIP directing group with aryl iodides/bromides has been achieved. Arylation occurs efficiently with a broad range of aryl halides and amides.

引用

页码：8353 / 8355

页数：3

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