GC-MS Based Plasma Metabolic Profiling of Type 2 Diabetes Mellitus

被引：25
作者：
Zeng, Maomao [1 ]
Che, Zhihong [2 ]
Liang, Yizeng [1 ]
Wang, Bing [1 ]
Chen, Xian [1 ]
Li, Hongdong [1 ]
Deng, Jiahui [1 ]
Zhou, Zhiguang [2 ]
机构：
[1] Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China
[2] Cent S Univ, Xiangya Hosp 2, Ctr Diabet, Changsha 410011, Hunan, Peoples R China
来源：
CHROMATOGRAPHIA | 2009年 / 69卷 / 9-10期
关键词：
Gas chromatography-mass spectrometry; Principal component analysis; Partial least squares-discriminant analysis; Metabolic profiling; Type 2 diabetes mellitus; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; AMINO-ACID-METABOLISM; MASS-SPECTROMETRY; CAPILLARY-ELECTROPHORESIS; LIQUID-CHROMATOGRAPHY; METABONOMIC ANALYSIS; INSULIN-RESISTANCE; BIOLOGICAL-FLUIDS; RAT; BIOMARKERS;
D O I：
10.1365/s10337-009-1040-0
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Gas chromatography-mass spectrometry based metabolic profiling was used to characterize metabolic profiles in type 2 diabetes mellitus. We found distinct differences between type 2 diabetic patients and healthy controls, type 2 diabetic patients before and after treatment of the plasma metabolic profiles. Furthermore, levels of lactate, alpha-hydroxyisobutyric acid, phosphate, 1-monopalmitin and 1-monostearin were closely correlated with the disease state and may be considered as potential biomarkers for type 2 diabetes mellitus. The results demonstrated that plasma GC-MS metabolic profiling combined with multi- and uni-variate statistical analysis techniques provided an efficient way of depicting metabolic perturbations of diseases, and it may also be able to assist disease and treatment surveillance.
引用
收藏
页码：941 / 948
页数：8
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