CRP Gene (1059G>C) Polymorphism and Its Plasma Levels in Ischemic Stroke and Hemorrhagic Stroke in a South Indian Population

被引：18
|
作者：
Das, Satrupa [1 ,2 ,3 ]
Roy, Sitara [1 ,2 ,3 ]
Kaul, Subhash [4 ]
Jyothy, Akka [1 ,2 ]
Munshi, Anjana [1 ,2 ,5 ]
机构：
[1] Osmania Univ, Inst Genet, Hyderabad 500016, Andhra Pradesh, India
[2] Osmania Univ, Hosp Genet Dis, Hyderabad 500016, Andhra Pradesh, India
[3] Dr NTR Univ Hlth Sci, Vijayawada, Andhra Pradesh, India
[4] Nizams Inst Med Sci, Hyderabad 500082, Andhra Pradesh, India
[5] Cent Univ Punjab, Sch Hlth Sci, Ctr Human Genet, Bathinda, Punjab, India
来源：
INFLAMMATION | 2014年 / 37卷 / 05期
关键词：
C-reactive protein; 1059G > C; ischemic stroke; hemorrhagic stroke; inflammatory marker; C-REACTIVE PROTEIN; RISK-FACTORS; DISEASE; ATHEROSCLEROSIS; EPIDEMIOLOGY; ASSOCIATION; MECHANISMS; SUBTYPES; PHASE;
D O I：
10.1007/s10753-014-9897-y
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the present study, we evaluated the association of 1059G > C polymorphism in C-reactive protein (CRP) gene with the risk of ischemic and hemorrhagic strokes. We did not find a significant association of this polymorphism with stroke. However, 2 % of mutants were observed in hemorrhagic stroke patients with a 0.01 frequency for the C allele. We also estimated the high-sensitivity C-reactive protein (hsCRP) levels in hemorrhagic stroke and compared the levels with our already published data on ischemic stroke. The hsCRP level in hemorrhagic stroke was found to be significantly elevated in comparison with that in controls (p < 0.001). However, there was no difference in the mean value of hsCRP levels between types of stroke. In conclusion, the G > C polymorphism in the promoter region of the CRP gene is not abundant in the population and cannot be connected with different hsCRP levels and stroke prediction. The CRP level is a useful marker in stroke, but cannot help in differentiating between types of stroke.
引用
收藏
页码：1683 / 1688
页数：6
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