Regulation of mTORC2 Signaling

被引：153

作者：

Fu, Wenxiang ^{[1
,2
]}

Hall, Michael N. ^{[2
]}

机构：

[1] Yunnan Univ, Ctr Life Sci, Sch Life Sci, Kunming 650500, Yunnan, Peoples R China

[2] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

GENES | 2020年 / 11卷 / 09期

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

mTOR; mTORC2; signaling; Akt; signaling crosstalk; GROWTH-FACTOR RECEPTOR; COMPLEX; 2; MAMMALIAN TARGET; PHOSPHOPROTEOME REVEALS; MOTIF PHOSPHORYLATION; PROTEIN COMPLEXES; CELL-SURVIVAL; KINASE-B; AKT; RICTOR;

D O I：

10.3390/genes11091045

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.

引用

页码：1 / 19

页数：19

共 137 条

[121] Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle [J].

von Maltzahn, Julia ;

Bentzinger, C. Florian ;

Rudnicki, Michael A. .

NATURE CELL BIOLOGY, 2012, 14 (02) :186-191

[122] TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling [J].

Wang, Bin ;

Jie, Zuliang ;

Joo, Donghyun ;

Ordureau, Alban ;

Liu, Pengda ;

Gan, Wenjian ;

Guo, Jianping ;

Zhang, Jinfang ;

North, Brian J. ;

Dai, Xiangpeng ;

Cheng, Xuhong ;

Bian, Xiuwu ;

Zhang, Lingqiang ;

Harper, J. Wade ;

Sun, Shao-Cong ;

Wei, Wenyi .

NATURE, 2017, 545 (7654) :365-+

[123] Glycogen synthase kinase 3: A point of convergence for the host inflammatory response [J].

Wang, Huizhi ;

Brown, Jonathan ;

Martin, Michael .

CYTOKINE, 2011, 53 (02) :130-140

[124] Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae [J].

Wedaman, KP ;

Reinke, A ;

Anderson, S ;

Yates, J ;

McCaffery, JM ;

Powers, T .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (03) :1204-1220

[125] Identification of an oncogenic RAB protein [J].

Wheeler, Douglas B. ;

Zoncu, Roberto ;

Root, David E. ;

Sabatini, David M. ;

Sawyers, Charles L. .

SCIENCE, 2015, 350 (6257) :211-217

[126] PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor β expression and signaling [J].

Woo, So-Yon ;

Kim, Dong-Hwan ;

Jun, Chang-Bong ;

Kim, Young-Mi ;

Haar, Emilie Vander ;

Lee, Seong-il ;

Hegg, James W. ;

Bandhakavi, Sricharan ;

Griffin, Timothy J. ;

Kim, Do-Hyung .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (35) :25604-25612

[127] Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance [J].

Wu, Zhihao ;

Sawada, Tomoyo ;

Shiba, Kahori ;

Liu, Song ;

Kanao, Tomoko ;

Takahashi, Ryosuke ;

Hattori, Nobutaka ;

Imai, Yuzuru ;

Lu, Bingwei .

GENES & DEVELOPMENT, 2013, 27 (02) :157-162

[128] A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation [J].

Yang, Guang ;

Murashige, Danielle S. ;

Humphrey, Sean J. ;

James, David E. .

CELL REPORTS, 2015, 12 (06) :937-943

[129] mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR [J].

Yin, Yancun ;

Hua, Hui ;

Li, Minjing ;

Liu, Shu ;

Kong, Qingbin ;

Shao, Ting ;

Wang, Jiao ;

Luo, Yuanming ;

Wang, Qian ;

Luo, Ting ;

Jiang, Yangfu .

CELL RESEARCH, 2016, 26 (01) :46-65

[130] Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling [J].

Yu, Yonghao ;

Yoon, Sang-Oh ;

Poulogiannis, George ;

Yang, Qian ;

Ma, Xiaoju Max ;

Villen, Judit ;

Kubica, Neil ;

Hoffman, Gregory R. ;

Cantley, Lewis C. ;

Gygi, Steven P. ;

Blenis, John .

SCIENCE, 2011, 332 (6035) :1322-1326

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