Regulation of mTORC2 Signaling

被引：153

作者：

Fu, Wenxiang ^{[1
,2
]}

Hall, Michael N. ^{[2
]}

机构：

[1] Yunnan Univ, Ctr Life Sci, Sch Life Sci, Kunming 650500, Yunnan, Peoples R China

[2] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

GENES | 2020年 / 11卷 / 09期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

mTOR; mTORC2; signaling; Akt; signaling crosstalk; GROWTH-FACTOR RECEPTOR; COMPLEX; 2; MAMMALIAN TARGET; PHOSPHOPROTEOME REVEALS; MOTIF PHOSPHORYLATION; PROTEIN COMPLEXES; CELL-SURVIVAL; KINASE-B; AKT; RICTOR;

D O I：

10.3390/genes11091045

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.

引用

页码：1 / 19

页数：19

共 137 条

[101] Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B [J].

Scheid, MP ;

Marignani, PA ;

Woodgett, JR .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (17) :6247-6260

[102] The endosomal protein Appl1 mediates akt substrate specificity and cell survival in vertebrate development [J].

Schenck, Annette ;

Goto-Silva, Livia ;

Collinet, Claudio ;

Rhinn, Muriel ;

Giner, Angelika ;

Habermann, Bianca ;

Brand, Michael ;

Zerial, Marino .

CELL, 2008, 133 (03) :486-497

[103] Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling [J].

Schroder, Wayne A. ;

Buck, Marion ;

Cloonan, Nicole ;

Hancock, John F. ;

Suhrbier, Andreas ;

Sculley, Tom ;

Bushell, Gillian .

CELLULAR SIGNALLING, 2007, 19 (06) :1279-1289

[104] Phosphorylated Rho-GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras-GTP to regulate cell migration [J].

Senoo, Hiroshi ;

Kamimura, Yoichiro ;

Kimura, Reona ;

Nakajima, Akihiko ;

Sawai, Satoshi ;

Sesaki, Hiromi ;

Iijima, Miho .

NATURE CELL BIOLOGY, 2019, 21 (07) :867-+

[105] Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies [J].

Shah, OJ ;

Wang, ZY ;

Hunter, T .

CURRENT BIOLOGY, 2004, 14 (18) :1650-1656

[106] Insulin resistance causes inflammation in adipose tissue [J].

Shimobayashi, Mitsugu ;

Albert, Verena ;

Woelnerhanssen, Bettina ;

Frei, Irina C. ;

Weissenberger, Diana ;

Meyer-Gerspach, Anne Christin ;

Clement, Nicolas ;

Moes, Suzette ;

Colombi, Marco ;

Meier, Jerome A. ;

Swierczynska, Marta M. ;

Jeno, Paul ;

Beglinger, Christoph ;

Peterli, Ralph ;

Hall, Michael N. .

JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (04) :1538-1550

[107] Making new contacts: the mTOR network in metabolism and signalling crosstalk [J].

Shimobayashi, Mitsugu ;

Hall, Michael N. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (03) :155-162

[108] ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate [J].

Shin, Sejeong ;

Buel, Gwen R. ;

Wolgamott, Laura ;

Plas, David R. ;

Asara, John M. ;

Blenis, John ;

Yoon, Sang-Oh .

MOLECULAR CELL, 2015, 59 (03) :382-398

[109] mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action [J].

Soliman, Ghada A. ;

Acosta-Jaquez, Hugo A. ;

Dunlop, Elaine A. ;

Ekim, Bilgen ;

Maj, Nicole E. ;

Tee, Andrew R. ;

Fingar, Diane C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (11) :7866-7879

[110] Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors [J].

Sommer, Eeva M. ;

Dry, Hannah ;

Cross, Darren ;

Guichard, Sylvia ;

Davies, Barry R. ;

Alessi, Dario R. .

BIOCHEMICAL JOURNAL, 2013, 452 :499-508

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