Regulation of mTORC2 Signaling

被引：153

作者：

Fu, Wenxiang ^{[1
,2
]}

Hall, Michael N. ^{[2
]}

机构：

[1] Yunnan Univ, Ctr Life Sci, Sch Life Sci, Kunming 650500, Yunnan, Peoples R China

[2] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

GENES | 2020年 / 11卷 / 09期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

mTOR; mTORC2; signaling; Akt; signaling crosstalk; GROWTH-FACTOR RECEPTOR; COMPLEX; 2; MAMMALIAN TARGET; PHOSPHOPROTEOME REVEALS; MOTIF PHOSPHORYLATION; PROTEIN COMPLEXES; CELL-SURVIVAL; KINASE-B; AKT; RICTOR;

D O I：

10.3390/genes11091045

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.

引用

页码：1 / 19

页数：19

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