Regulating cell death at, on, and in membranes

被引：57

作者：

Chi, Xiaoke ^{[1
]}

Kale, Justin ^{[2
]}

Leber, Brian ^{[3
]}

Andrews, David W. ^{[1
,2
,4
,5
]}

机构：

[1] McMaster Univ, Dept Chem & Chem Biol, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada

[3] McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada

[4] Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada

[5] Univ Toronto, Dept Biochem, Toronto, ON, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2014年 / 1843卷 / 09期

基金：

加拿大健康研究院;

关键词：

Apoptosis; Bcl-2; family; Endoplasmic reticulum; Mitochondrion; Membrane; Embedded Together; ENDOPLASMIC-RETICULUM STRESS; BCL-2; FAMILY-MEMBER; MITOCHONDRIAL OUTER-MEMBRANE; CYTOCHROME-C RELEASE; BH3-ONLY PROTEIN BIM; ANTI-APOPTOTIC MCL-1; ER STRESS; CONFORMATIONAL-CHANGES; BAX ACTIVATION; PEPTIDE COMPLEX;

D O I：

10.1016/j.bbamcr.2014.06.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bcl-2 family proteins are central regulators of apoptosis. Various family members are located in the cytoplasm, endoplasmic reticulum, and mitochondrial outer membrane in healthy cells. However during apoptosis most of the interactions between family members that determine the fate of the cell occur at the membranes of intracellular organelles. It has become evident that interactions with membranes play an active role in the regulation of Bcl-2 family protein interactions. Here we provide an overview of various models proposed to explain how the Bcl-2 family regulates apoptosis and discuss how membrane binding affects the structure and function of each of the three categories of Bcl-2 proteins (pro-apoptotic, pore-forming, and anti-apoptotic). We also examine how the Bcl-2 family regulates other aspects of mitochondrial and ER physiology relevant to cell death. (C) 2014 Published by Elsevier B.V.

引用

页码：2100 / 2113

页数：14

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