Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages

被引：10

作者：

Dushkin, M. I. ^{[1
]}

Khoshchenko, O. M. ^{[1
]}

Kudinova, E. N. ^{[1
]}

Schwartz, Ya. Sh. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Therapy, Siberian Div, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 02期

关键词：

macrophages; hydroxysterols; atorvastatin; tumor necrosis factor-alpha; interleukin-10;

D O I：

10.1007/s10517-006-0136-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Preincubation of macrophages with atorvastatin, cholesterol, 25-, 27-hydroxycholesterol, and 7-ketocholesterol reduced the level of TNF-alpha to 10, 61, 13, 64.5, and 82%, respectively. Addition of mevalonate to the preincubation medium canceled the effects atorvastatin, cholesterol, and 7-ketocholesterol, but not the effects of 25- and 27-hydroxycholesterols. Atorvastatin increased the level of IL-10 by 41%, while 7-ketocholesterol and 25-hydroxycholesterol inhibited its secretion by 48 and 55%.

引用

页码：233 / 235

页数：3

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