Epigenetic reprogramming in mammalian nuclear transfer

被引：5
|
作者：
Li, SJ
Du, WH
Li, N [1 ]
机构：
[1] China Agr Univ, State Key Lab Agrobiotechnol, Beijing 100094, Peoples R China
[2] Hebei Agr Univ, Coll Life Sci, Dept Biochem & Mol Biol, Baoding 071001, Peoples R China
来源：
CHINESE SCIENCE BULLETIN | 2004年 / 49卷 / 08期
关键词：
somatic nuclear transfer; epigenetic reprogramming; DNA methylation; histon acetylation; X-chromosome activation; telomere; imprinting; gene expression;
D O I：
10.1360/04wc0025
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Somatic cloning has been succeeded in some species, but the cloning efficiency is very low, which limits the application of the technique in many areas of research and biotechnology. The cloning of mammals by somatic cell nuclear transfer (NT) requires epigenetic reprogramming of the differentiated state of donor cell to a totipotent, embryonic ground state. Accumulating evidence indicates that incomplete or inappropriate epigenetic reprogramming of donor nuclei is likely to be the primary cause of failures in nuclear transfer. This review summarizes the roles of various epigenetic mechanisms, including DNA methylation, histone acetylation, imprinting, X-chromosome inactivation, telomere maintenance and expressions of development-related genes on somatic nuclear transfer.
引用
收藏
页码：766 / 771
页数：6
相关论文
共 50 条
  • [1] Epigenetic reprogramming in mammalian nuclear transfer
    Shi, W
    Zakhartchenko, V
    Wolf, E
    DIFFERENTIATION, 2003, 71 (02) : 91 - 113
  • [2] Epigenetic reprogramming in mammalian nuclear transfer
    LI Shijie1
    2. Department of Biochemistry and Molecular Biology
    ChineseScienceBulletin, 2004, (08) : 766 - 771
  • [3] Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer
    Dean, W
    Santos, F
    Reik, W
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2003, 14 (01) : 93 - 100
  • [4] Epigenetic Reprogramming by Somatic Cell Nuclear Transfer in Primates
    Sparman, Michelle
    Dighe, Vikas
    Sritanaudomchai, Hathaitip
    Ma, Hong
    Ramsey, Cathy
    Pedersen, Darlene
    Clepper, Lisa
    Nighot, Prashant
    Wolf, Don
    Hennebold, Jon
    Mitalipov, Shoukhrat
    STEM CELLS, 2009, 27 (06) : 1255 - 1264
  • [5] Reprogramming of epigenetic inheritance by somatic cell nuclear transfer
    Tian, XC
    REPRODUCTIVE BIOMEDICINE ONLINE, 2004, 8 (05) : 501 - 508
  • [6] Epigenetic reprogramming in mammalian development
    Reik, W
    Dean, W
    Walter, J
    SCIENCE, 2001, 293 (5532) : 1089 - 1093
  • [7] Epigenetic reprogramming in the mammalian germline
    Hsu, Fei-Man
    Clark, Amander
    Chen, Pao-Yang
    ONCOTARGET, 2015, 6 (34) : 35151 - 35152
  • [8] Epigenetic reprogramming in mammalian reproduction
    Santenard, Angele
    Torres-Padilla, Maria-Elena
    EPIGENETICS, 2009, 4 (02) : 80 - 84
  • [9] Nuclear transfer for the study of epigenetic dynamics in mammalian development
    Ogura, Atsuo
    GENES & GENETIC SYSTEMS, 2012, 87 (06) : 371 - 371
  • [10] Nuclear reprogramming and epigenetic rejuvenation
    Singh, Prim B.
    Zacouto, Fred
    JOURNAL OF BIOSCIENCES, 2010, 35 (02) : 315 - 319
12345