Antibacterial activity of Taxodium ascendens Diterpenes against Methicillin-resistant Staphylococcus aureus

被引：2
作者：
Starks, Courtney M. [1 ]
Norman, Vanessa L. [1 ]
Williams, Russell B. [1 ]
Goering, Matt G. [1 ]
Rice, Stephanie M. [1 ]
O'Neil-Johnson, Mark [1 ]
Eldridge, Gary R. [1 ]
机构：
[1] Sequoia Sci, Lead Discovery & Rapid Struct Elucidat Grp, St Louis, MO 63114 USA
来源：
NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 08期
关键词：
Diterpenoids; MRSA; Cupressaceae; Taxodium ascendens;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens. Of these, demethylcryptojaponol (2), 6-hydroxysalvinolone (3), hydroxyferruginol (4), and hinokiol (5) demonstrated potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MASA). These compounds represent a class of synthetically accessible compounds that could be further developed for treatment of drug-resistant bacterial infections.
引用
收藏
页码：1129 / 1130
页数：2
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  • [1] Taxonomy and nomenclature of baldcypress, pondcypress, and montezuma cypress: One, two, or three species?
    Denny, Geoffrey C.
    Arnold, Michael A.
    [J]. HORTTECHNOLOGY, 2007, 17 (01) : 125 - 127
  • [2] High-throughput method for the production and analysis of large natural product libraries for drug discovery
    Eldridge, GR
    Vervoort, HC
    Lee, CM
    Cremin, PA
    Williams, CT
    Hart, SM
    Goering, MG
    O'Neil-Johnson, M
    Zeng, L
    [J]. ANALYTICAL CHEMISTRY, 2002, 74 (16) : 3963 - 3971
  • [3] Application of capillary-scale NMR for the structure determination of phytochemicals
    Hu, JF
    Garo, E
    Yoo, HD
    Cremin, PA
    Zeng, L
    Goering, MG
    O'Neil-Johnson, M
    Eldridge, GR
    [J]. PHYTOCHEMICAL ANALYSIS, 2005, 16 (02) : 127 - 133
  • [4] Comparative studies on physiological and biochemical adaptation of Taxodium distichum and Taxodium ascendens seedlings to different soil water regimes
    Li, Changxiao
    Zhong, Zhangcheng
    Geng, Yanghui
    Schneider, Rebecca
    [J]. PLANT AND SOIL, 2010, 329 (1-2) : 481 - 494
  • [5] Virulence Gene Expression in Human Community-Acquired Staphylococcus aureus Infection
    Loughman, Jennifer A.
    Fritz, Stephanie A.
    Storch, Gregory A.
    Hunstad, David A.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (03) : 294 - 301
  • [6] Novel Pentadecenyl Tetrazole Enhances Susceptibility of Methicillin-Resistant Staphylococcus aureus Biofilms to Gentamicin
    Olson, Krista M.
    Starks, Courtney M.
    Williams, Russell B.
    O'Neil-Johnson, Mark
    Huang, Zhongping
    Ellis, Michael
    Reilly, John E.
    Eldridge, Gary R.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (08) : 3691 - 3695
  • [7] Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE
    Yang, ZX
    Kitano, Y
    Chiba, K
    Shibata, N
    Kurokawa, H
    Doi, Y
    Arakawa, Y
    Tada, M
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (02) : 347 - 356
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