Antibacterial activity of Taxodium ascendens Diterpenes against Methicillin-resistant Staphylococcus aureus

被引：2

作者：

Starks, Courtney M. ^{[1
]}

Norman, Vanessa L. ^{[1
]}

Williams, Russell B. ^{[1
]}

Goering, Matt G. ^{[1
]}

Rice, Stephanie M. ^{[1
]}

O'Neil-Johnson, Mark ^{[1
]}

Eldridge, Gary R. ^{[1
]}

机构：

[1] Sequoia Sci, Lead Discovery & Rapid Struct Elucidat Grp, St Louis, MO 63114 USA

来源：

NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 08期

关键词：

Diterpenoids; MRSA; Cupressaceae; Taxodium ascendens;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens. Of these, demethylcryptojaponol (2), 6-hydroxysalvinolone (3), hydroxyferruginol (4), and hinokiol (5) demonstrated potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MASA). These compounds represent a class of synthetically accessible compounds that could be further developed for treatment of drug-resistant bacterial infections.

引用

页码：1129 / 1130

页数：2

共 7 条

[1] Taxonomy and nomenclature of baldcypress, pondcypress, and montezuma cypress: One, two, or three species? [J].

Denny, Geoffrey C. ;

Arnold, Michael A. .

HORTTECHNOLOGY, 2007, 17 (01) :125-127

[2] High-throughput method for the production and analysis of large natural product libraries for drug discovery [J].

Eldridge, GR ;

Vervoort, HC ;

Lee, CM ;

Cremin, PA ;

Williams, CT ;

Hart, SM ;

Goering, MG ;

O'Neil-Johnson, M ;

Zeng, L .

ANALYTICAL CHEMISTRY, 2002, 74 (16) :3963-3971

[3] Application of capillary-scale NMR for the structure determination of phytochemicals [J].

Hu, JF ;

Garo, E ;

Yoo, HD ;

Cremin, PA ;

Zeng, L ;

Goering, MG ;

O'Neil-Johnson, M ;

Eldridge, GR .

PHYTOCHEMICAL ANALYSIS, 2005, 16 (02) :127-133

[4] Comparative studies on physiological and biochemical adaptation of Taxodium distichum and Taxodium ascendens seedlings to different soil water regimes [J].

Li, Changxiao ;

Zhong, Zhangcheng ;

Geng, Yanghui ;

Schneider, Rebecca .

PLANT AND SOIL, 2010, 329 (1-2) :481-494

[5] Virulence Gene Expression in Human Community-Acquired Staphylococcus aureus Infection [J].

Loughman, Jennifer A. ;

Fritz, Stephanie A. ;

Storch, Gregory A. ;

Hunstad, David A. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (03) :294-301

[6] Novel Pentadecenyl Tetrazole Enhances Susceptibility of Methicillin-Resistant Staphylococcus aureus Biofilms to Gentamicin [J].

Olson, Krista M. ;

Starks, Courtney M. ;

Williams, Russell B. ;

O'Neil-Johnson, Mark ;

Huang, Zhongping ;

Ellis, Michael ;

Reilly, John E. ;

Eldridge, Gary R. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (08) :3691-3695

[7] Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE [J].

Yang, ZX ;

Kitano, Y ;

Chiba, K ;

Shibata, N ;

Kurokawa, H ;

Doi, Y ;

Arakawa, Y ;

Tada, M .

BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (02) :347-356

← 1 →