Sentinel Node Status and Immunosuppression: Recurrence Factors in Localized Merkel Cell Carcinoma

被引：23

作者：

Jouary, Thomas ^{[1
]}

Kubica, Emeline ^{[1
]}

Dalle, Stephane ^{[2
]}

Pages, Cecile ^{[3
]}

Duval-Modeste, Anne-Benedicte ^{[4
]}

Guillot, Bernard ^{[5
]}

Mansard, Sandrine ^{[6
]}

Saiag, Philippe ^{[7
]}

Aubin, Francois ^{[8
]}

Bedane, Christophe ^{[9
]}

Dalac, Sophie ^{[10
]}

Dompmartin, Anne ^{[11
]}

Granel-Brocard, Florence ^{[12
]}

Lok, Catherine ^{[13
]}

Stoebner, Pierre-Emmanuel ^{[14
]}

Lacour, Jean-Philippe ^{[15
]}

Leccia, Marie-Therese ^{[16
]}

Diallo, Abou ^{[17
]}

Ezzedine, Khaled ^{[1
]}

Mateus, Christina ^{[18
]}

机构：

[1] CHU Bordeaux, Hop St Andre, Serv Dermatol, Bordeaux, France

[2] Hosp Civils Lyon, Canc Res Ctr Lyon, Lyon, France

[3] Hop St Louis, AP HP, St Louis, France

[4] CHU Rouen, Hop Charles Nicolle, Rouen, France

[5] CHU Montpellier, Hop Edouard Herriot, Montpellier, France

[6] CHRU Clermont Ferrand, Hop Estaing, Paris, France

[7] Hop Ambroise Pare, AP HP, Paris, France

[8] CHU Besancon, Hop St Jacques, Besancon, France

[9] CHU Limoges, Hop Dupuytren, Limoges, France

[10] CHU Dijon, Hop Bocage, Dijon, France

[11] CHU Caen, Hop Clemenceau, Caen, France

[12] CHU Nancy, Hop Brabois, Nancy, France

[13] CHU Amiens, Hop Sud, Amiens, France

[14] CHU Nimes, Nimes, France

[15] CHU Nice, Hop Archet, Nice, France

[16] CHU Grenoble, Hop Michallon, Grenoble, France

[17] Univ Bordeaux 2, Inst Sante Publ Epidemiol & Dev, F-33076 Bordeaux, France

[18] Inst Gustave Roussy, Serv Dermatol, Villejuif, France

来源：

ACTA DERMATO-VENEREOLOGICA | 2015年 / 95卷 / 07期

关键词：

Merkel cell carcinoma; sentinel node; radiotherapy; prognostic; SINGLE INSTITUTION; RADIATION-THERAPY; SURVIVAL; METAANALYSIS; BIOPSY; SKIN;

D O I：

10.2340/00015555-2099

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The prognostic value of the sentinel lymph node in Merkel cell carcinoma (MCC) has been examined previously in heterogeneous retrospective studies. The current retrospective study included a homogeneous population of patients with a localized MCC, all staged with sentinel lymph node biopsy. Factors associated with 3-year progression-free survival were analysed using logistic regression. The sentinel lymph node was positive in 32% of patients. The recurrence rate was 26.9%. In first analyses (n=108), gender (p=0.0115) and the presence of immunosuppression (p=0.0494) were the only significant independent factors. In further analyses (n=80), excluding patients treated with regional radiotherapy, sentinel lymph node status was the only significant prognostic factor (p=0.0281). Immunosuppression and positive sentinel lymph node are associated with a worse prognosis in patients with MCC. Nodal irradiation impacts on the prognostic value of the sentinel lymph node status.

引用

页码：835 / 840

页数：6

共 26 条

[1] Epidemiology of primary Merkel cell carcinoma in the United States [J].

Agelli, M ;

Clegg, LX .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 49 (05) :832-841

[2] Merkel cell carcinoma: Prognosis and treatment of patients from a single institution [J].

Allen, PJ ;

Bowne, WB ;

Jaques, DP ;

Brennan, MF ;

Busam, K ;

Coit, DG .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (10) :2300-2309

[3]

Becker J, 2008, J DTSCH DERMATOL GES, V6, pS16

[4] Merkel Cell Carcinoma, Version 1.2014 [J].

Bichakjian, Christopher K. ;

Olencki, Thomas ;

Alam, Murad ;

Andersen, James S. ;

Berg, Daniel ;

Bowen, Glen M. ;

Cheney, Richard T. ;

Daniels, Gregory A. ;

Glass, L. Frank ;

Grekin, Roy C. ;

Grossman, Kenneth ;

Ho, Alan L. ;

Lewis, Karl D. ;

Lydiatt, Daniel D. ;

Morrison, William H. ;

Nehal, Kishwer S. ;

Nelson, Kelly C. ;

Nghiem, Paul ;

Perlis, Clifford S. ;

Shaha, Ashok R. ;

Thorstad, Wade L. ;

Tuli, Malika ;

Urist, Marshall M. ;

Wang, Timothy S. ;

Werchniak, Andrew E. ;

Wong, Sandra L. ;

Zic, John A. ;

Hoffmann, Karin G. ;

McMillian, Nicole R. ;

Ho, Maria .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2014, 12 (03) :410-424

[5] Guidelines for the diagnosis and treatment of Merkel cell carcinoma - Cutaneous Oncology Group of the French Society of Dermatology [J].

Boccara, Olivia ;

Girard, Celine ;

Mortier, Laurent ;

Bens, Guido ;

Saiag, Philippe ;

Guillot, Bernard .

EUROPEAN JOURNAL OF DERMATOLOGY, 2012, 22 (03) :375-379

[6]

Coit DG, 2001, ANN SURG ONCOL, V8, P187, DOI 10.1245/aso.2001.8.3.187

[7] The predictive value of imaging studies in evaluating regional lymph node involvement in Merkel cell carcinoma [J].

Colgan, Michael B. ;

Tarantola, Tina I. ;

Weaver, Amy L. ;

Wiseman, Gregory A. ;

Roenigk, Randall K. ;

Brewer, Jerry D. ;

Otley, Clark C. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2012, 67 (06) :1250-1256

[8] Recurrence and Survival in Patients Undergoing Sentinel Lymph Node Biopsy for Merkel Cell Carcinoma: Analysis of 153 Patients from a Single Institution [J].

Fields, Ryan C. ;

Busam, Klaus J. ;

Chou, Joanne F. ;

Panageas, Katherine S. ;

Pulitzer, Melissa P. ;

Kraus, Dennis H. ;

Brady, Mary S. ;

Coit, Daniel G. .

ANNALS OF SURGICAL ONCOLOGY, 2011, 18 (09) :2529-2537

[9] Merkel cell carcinoma adjuvant therapy: Current data support radiation but not chemotherapy [J].

Garneski, Kelly M. ;

Nghiem, Paul .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2007, 57 (01) :166-169

[10] Merkel cell carcinoma [J].

Goessling, W ;

McKee, PH ;

Mayer, RJ .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (02) :588-598

← 1 2 3 →