Cancer nanomedicine for combination cancer immunotherapy

被引：767
作者：
Nam, Jutaek [1 ,2 ]
Son, Sejin [1 ,2 ]
Park, Kyung Soo [2 ,3 ]
Zou, Weiping [4 ,5 ]
Shea, Lonnie D. [2 ,3 ,6 ]
Moon, James J. [1 ,2 ,3 ,5 ]
机构：
[1] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Inst Biointerfaces, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Surg, Sch Med, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Sch Med, Grad Program Immunol, Ann Arbor, MI 48109 USA
[6] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA
来源：
NATURE REVIEWS MATERIALS | 2019年 / 4卷 / 06期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
CD8(+) T-CELLS; IMMUNE CHECKPOINT BLOCKADE; IN-SITU VACCINATION; PHOTODYNAMIC THERAPY; DENDRITIC CELLS; TUMOR MICROENVIRONMENT; ANTITUMOR IMMUNITY; RADIATION-THERAPY; PHOTOTHERMAL THERAPY; ANTIGEN-PRESENTATION;
D O I：
10.1038/s41578-019-0108-1
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Cancer immunotherapy is revolutionizing oncology. However, dose-limiting toxicities and low patient response rates remain major challenges in the clinic. Cancer nanomedicine in combination with immunotherapies offers the possibility to amplify antitumour immune responses and to sensitize tumours to immunotherapies in a safe and effective manner. In this Review, we discuss opportunities for combination immunotherapy based on nanoparticle platforms designed for chemotherapy, photothermal therapy, photodynamic therapy, radiotherapy and gene therapy. We highlight how nanoparticles can be used to reprogramme the immunosuppressive tumour microenvironment and to trigger systemic antitumour immunity, synergizing with immunotherapies against advanced cancer. Finally, we discuss strategies to improve tumour and immune cell targeting while minimizing toxicity and immune-related adverse events, and we explore the potential of theranostic nanoparticles for combination immunotherapy.
引用
收藏
页码：398 / 414
页数：17
相关论文
共 224 条
[1]   Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles [J].
Abadeer, Nardine S. ;
Murphy, Catherine J. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2016, 120 (09) :4691-4716
[2]   New photosensitizers for photodynamic therapy [J].
Abrahamse, Heidi ;
Hamblin, Michael R. .
BIOCHEMICAL JOURNAL, 2016, 473 :347-364
[3]   Protein Dynamics Associated with Failed and Rescued Learning in the Ts65Dn Mouse Model of Down Syndrome [J].
Ahmed, Md Mahiuddin ;
Dhanasekaran, A. Ranjitha ;
Block, Aaron ;
Tong, Suhong ;
Costa, Alberto C. S. ;
Stasko, Melissa ;
Gardiner, Katheleen J. .
PLOS ONE, 2015, 10 (03)
[4]   STAT3 Silencing in Dendritic Cells by siRNA Polyplexes Encapsulated in PLGA Nanoparticles for the Modulation of Anticancer Immune Response [J].
Alshamsan, Aws ;
Haddadi, Azita ;
Hamdy, Samar ;
Samuel, John ;
El-Kadi, Ayman O. S. ;
Uludag, Hasan ;
Lavasanifar, Afsaneh .
MOLECULAR PHARMACEUTICS, 2010, 7 (05) :1643-1654
[5]   Intratumoral Delivery of Immunotherapy-Act Locally, Think Globally [J].
Angela Aznar, M. ;
Tinari, Nicola ;
Rullan, Antonio J. ;
Sanchez-Paulete, Alfonso R. ;
Rodriguez-Ruiz, Maria E. ;
Melero, Ignacio .
JOURNAL OF IMMUNOLOGY, 2017, 198 (01) :31-39
[6]  
[Anonymous], 2017, SCI REP UK
[7]  
[Anonymous], 2012, FRONT ONCOL
[8]   In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy [J].
Arlauckas, Sean P. ;
Garris, Christopher S. ;
Kohler, Rainer H. ;
Kitaoka, Maya ;
Cuccarese, Michael F. ;
Yang, Katherine S. ;
Miller, Miles A. ;
Carlson, Jonathan C. ;
Freeman, Gordon J. ;
Anthony, Robert M. ;
Weissleder, Ralph ;
Pittet, Mikael J. .
SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (389)
[9]   Near-infrared light-responsive inorganic nanomaterials for photothermal therapy [J].
Bao, Zhihong ;
Liu, Xuerong ;
Liu, Yangdi ;
Liu, Hongzhuo ;
Zhao, Kun .
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 11 (03) :349-364
[10]   Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction [J].
Bauer, Christian A. ;
Kim, Edward Y. ;
Marangoni, Francesco ;
Carrizosa, Esteban ;
Claudio, Natalie M. ;
Mempel, Thorsten R. .
JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (06) :2425-2440
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