Future directions for anti-biofilm therapeutics targeting Candida

被引：65

作者：

Nett, Jeniel E. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Med Microbiol & Immunol, Dept Med, Madison, WI 53705 USA

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2014年 / 12卷 / 03期

关键词：

amphotericin B; antifungal; azole; biofilm; Candida; echinocandin; lock therapy; matrix; resistance; IN-VITRO ACTIVITY; ALBICANS BIOFILMS; AMPHOTERICIN-B; FLUCONAZOLE RESISTANCE; ANTIFUNGAL AGENTS; MURINE MODEL; INVASIVE CANDIDIASIS; EFFLUX PUMPS; FULVIC-ACID; MATRIX;

D O I：

10.1586/14787210.2014.885838

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

While proliferating in its most common mode of growth, a biofilm, Candida spp. exhibit increased resistance to available antifungal agents. These adherent communities are difficult to eradicate and often responsible for treatment failures. New therapies are urgently needed to treat a variety of Candida biofilm infections in the medical setting. This review discusses the medical relevance of Candida biofilms, the drug resistance associated with this mode of growth, and approaches to combat these resilient infections.

引用

页码：375 / 382

页数：8

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