Immunopathogenesis of granulomas in chronic autoinflammatory diseases

被引：51

作者：

Timmermans, Wilhelmina Maria Cornelia ^{[1
,2
,3
]}

van Laar, Jan Alexander Michael ^{[1
,2
]}

van Hagen, Petrus Martinus ^{[1
,2
]}

van Zelm, Menno Cornelis ^{[3
]}

机构：

[1] Univ Med Ctr, Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[2] Univ Med Ctr, Erasmus MC, Dept Immunol, Rotterdam, Netherlands

[3] Monash Univ, Cent Clin Sch, Dept Immunol & Pathol, Melbourne, Vic, Australia

来源：

CLINICAL & TRANSLATIONAL IMMUNOLOGY | 2016年 / 5卷

关键词：

REGULATORY T-CELLS; COMMON VARIABLE IMMUNODEFICIENCY; TUMOR-NECROSIS-FACTOR; INVASIVE ESCHERICHIA-COLI; AVIUM SUBSPECIES PARATUBERCULOSIS; ANTIBODY-DEFICIENCY SYNDROME; INFLAMMATORY BOWEL DISEASES; MULTINUCLEATED GIANT-CELLS; INTESTINAL LAMINA PROPRIA; ACTIVE CROHNS-DISEASE;

D O I：

10.1038/cti.2016.75

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Granulomas are clusters of immune cells. These structures can be formed in reaction to infection and display signs of necrosis, such as in tuberculosis. Alternatively, in several immune disorders, such as sarcoidosis, Crohn's disease and common variable immunodeficiency, non-caseating granulomas are formed without an obvious infectious trigger. Despite advances in our understanding of the human immune system, the pathogenesis underlying these non-caseating granulomas in chronic inflammatory diseases is still poorly understood. Here, we review the current knowledge about the immunopathogenesis of granulomas, and we discuss how the involved immune cells can be targeted with novel therapeutics.

引用

页数：12

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