The pharmacology and clinical efficacy of matricaria recutita L.: a systematic review of in vitro, in vivo studies and clinical trials

This systematic review shows the effectiveness of Matricaria chamomilla for improving health. Original papers and case reports published during 2014-2018 in PubMed, Science Direct and Scopus were included. Most studies were in vitro, performed with extracts, in 2018, and originated from Iran. In vitro assays focused mainly on antimicrobial, antiparasitic and antioxidant activities. In vivo studies specially investigated organ and tissue protective activity of chamomile. Clinical trials have validated some of these in vitro and in vivo pharmacological activities (diabetes mellitus, hypertension and pain). Future preclinical and clinical investigations should be aimed at deeping into pure compounds responsible for activities.