Characterizing the viscoelastic behaviour of poly(lactide-co-glycolide acid)-hydroxyapatite foams

被引：5

作者：

Leung, Linus H. ^{[1
]}

Naguib, Hani E. ^{[1
]}

机构：

[1] Inst Biomat & Biomed Engn, Dept Mat Sci & Engn, Dept Mech & Ind Engn, Toronto, ON M5S 3G8, Canada

来源：

JOURNAL OF CELLULAR PLASTICS | 2013年 / 49卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Viscoelastic properties; biocompatible polymer; nano-composites; gas foaming; salt leaching; scaffolds; MESENCHYMAL STEM-CELLS; BONE-FORMATION; LOW-MAGNITUDE; SCAFFOLDS; ARCHITECTURE; FREQUENCY;

D O I：

10.1177/0021955X13503842

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The viscoelasticity of poly(lactide-co-glycolid acid) 75/25 and hydroxyapatite composite open-pore foams were examined in this study. The foams were fabricated using the gas foaming/salt leaching process, and two specific experiments were performed. The first was to test the viscoelastic dependency of the foams on the load frequency, and the second was to measure the creep of the foams under a static load. The experiments showed that the viscoelasticity of the foams did not vary with the addition nano-hydroxyapatite particles, but the environment of testing significantly affected these properties. These results can be used to better understand the behaviour of the scaffolds when in the physiological environment.

引用

页码：497 / 505

页数：9

共 16 条

[1]

[Anonymous], 2008, DYNAMIC MECH ANAL, DOI DOI 10.1201/9781420053135

[2] Semi-degradable scaffold for articular cartilage replacement [J].

Charlton, Devon C. ;

Peterson, Margaret G. E. ;

Spiller, Kara ;

Lowman, Anthony ;

Torzilli, Peter A. ;

Maher, Suzanne A. .

TISSUE ENGINEERING PART A, 2008, 14 (01) :207-213

[3] Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions [J].

Chen, Wen Li Kelly ;

Likhitpanichkul, Morakot ;

Ho, Anthony ;

Simmons, Craig A. .

BIOMATERIALS, 2010, 31 (09) :2489-2497

[4]

Hsu YY, 1997, J BIOMED MATER RES, V35, P107, DOI 10.1002/(SICI)1097-4636(199704)35:1<107::AID-JBM11>3.0.CO

[5]

2-G

[6] Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude [J].

Judex, Stefan ;

Lei, Xin ;

Han, Daniel ;

Rubin, Clinton .

JOURNAL OF BIOMECHANICS, 2007, 40 (06) :1333-1339

[7] TISSUE ENGINEERING [J].

LANGER, R ;

VACANTI, JP .

SCIENCE, 1993, 260 (5110) :920-926

[8] Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering [J].

Lutolf, MP ;

Hubbell, JA .

NATURE BIOTECHNOLOGY, 2005, 23 (01) :47-55

[9] Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering [J].

Mathieu, LM ;

Mueller, TL ;

Bourban, PE ;

Pioletti, DP ;

Müller, R ;

Månson, JAE .

BIOMATERIALS, 2006, 27 (06) :905-916

[10] 3D fiber-deposited scaffolds for tissue engineering: Influence of pores geometry and architecture on dynamic mechanical properties [J].

Moroni, L ;

de Wijn, JR ;

van Blitterswijk, CA .

BIOMATERIALS, 2006, 27 (07) :974-985

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