MMP-2: Expression, activation and inhibition

被引:180
作者
Corcoran, ML [1 ]
Hewitt, RE [1 ]
Kleiner, DE [1 ]
StetlerStevenson, WG [1 ]
机构
[1] NCI, EXTRACELL MATRIX PATHOL SECT,PATHOL LAB, DIV CLIN SCI,NIH, BETHESDA, MD 20892 USA
关键词
invasion; metastasis; gelatinase; activation;
D O I
10.1159/000468613
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Remodeling of the extracellular matrix (ECM), which occurs during many physiological and pathological processes, is one of the requisite events of cellular invasion. The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteases that are responsible for proteolytic degradation of specific ECM components. Regulating the activity of the MMPs at both mRNA and/or protein levels modulates the degradation of the ECM components which in turn alter cellular invasion. Although most MMPs are regulated via similar mechanisms at the mRNA and protein levels, the modulation of gelatinase A is unique. Understanding the mechanisms that regulate gelatinase A is important since expression and activation of this particular MMP is consistently correlated with a majority of malignant phenotypes. In this report, we will contrast the mechanisms that regulate the expression, activation and inhibition of gelatinase A with the mechanisms that modulate the rest the MMP family.
引用
收藏
页码:7 / 19
页数:13
相关论文
共 79 条
[1]   A FIBROBLAST ELONGATION-FACTOR PURIFIED FROM COLON-CARCINOMA CELLS SHARES SEQUENCE IDENTITY WITH TIMP-1 [J].
AGREZ, MV ;
MELDRUM, CJ ;
SIM, ATR ;
AEBERSOLD, RH ;
CLARK, IM ;
CAWSTON, TE ;
BURNS, GF .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 206 (02) :590-600
[2]   TUMOR-CELL INVASION INHIBITED BY TIMP-2 [J].
ALBINI, A ;
MELCHIORI, A ;
SANTI, L ;
LIOTTA, LA ;
BROWN, PD ;
STETLERSTEVENSON, WG .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (11) :775-779
[3]   ANGIOGENIC POTENTIAL IN-VIVO BY KAPOSIS-SARCOMA CELL-FREE SUPERNATANTS AND HIV-1 TAT PRODUCT - INHIBITION OF KS-LIKE LESIONS BY TISSUE INHIBITOR OF METALLOPROTEINASE-2 [J].
ALBINI, A ;
FONTANINI, G ;
MASIELLO, L ;
TACCHETTI, C ;
BIGINI, D ;
LUZZI, P ;
NOONAN, DM ;
STETLERSTEVENSON, WG .
AIDS, 1994, 8 (09) :1237-1244
[4]   GROWTH-STIMULATION OF HUMAN KERATINOCYTES BY TISSUE INHIBITOR OF METALLOPROTEINASES [J].
BERTAUX, B ;
HORNEBECK, W ;
EISEN, AZ ;
DUBERTRET, L .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1991, 97 (04) :679-685
[5]   MATRIX METALLOPROTEINASES - A REVIEW [J].
BIRKEDALHANSEN, H ;
MOORE, WGI ;
BODDEN, MK ;
WINDSOR, LJ ;
BIRKEDALHANSEN, B ;
DECARLO, A ;
ENGLER, JA .
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1993, 4 (02) :197-250
[6]   ANALYSIS OF THE TIMP-1/FIB-CL COMPLEX [J].
BODDEN, MK ;
WINDSOR, LJ ;
CATERINA, NCM ;
YERMOVSKY, A ;
BIRKEDALHANSEN, B ;
GALAZKA, G ;
ENGLER, JA ;
BIRKEDALHANSEN, H .
INHIBITION OF MATRIX METALLOPROTEINASES: THERAPEUTIC POTENTIAL, 1994, 732 :84-95
[7]   IDENTIFICATION OF A STIMULATOR OF STEROID-HORMONE SYNTHESIS ISOLATED FROM TESTIS [J].
BOUJRAD, N ;
OGWUEGBU, SO ;
GARNIER, M ;
LEE, CH ;
MARTIN, BM ;
PAPADOPOULOS, V .
SCIENCE, 1995, 268 (5217) :1609-1612
[8]  
BROWN PD, 1990, CANCER RES, V50, P6184
[9]   CELLULAR ACTIVATION OF THE 72 KDA TYPE-IV PROCOLLAGENASE/TIMP-2 COMPLEX [J].
BROWN, PD ;
KLEINER, DE ;
UNSWORTH, EJ ;
STETLERSTEVENSON, WG .
KIDNEY INTERNATIONAL, 1993, 43 (01) :163-170
[10]   THE C-TERMINAL REGION OF MEMBRANE TYPE MATRIX METALLOPROTEINASE IS A FUNCTIONAL TRANSMEMBRANE DOMAIN REQUIRED FOR PRO-GELATINASE-C ACTIVATION [J].
CAO, J ;
SATO, H ;
TAKINO, T ;
SEIKI, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (02) :801-805