The HIV-1 Entry Process: A Stoichiometric View

被引：39

作者：

Brandenberg, Oliver F. ^{[1
,3
]}

Magnus, Carsten ^{[1
]}

Regoes, Roland R. ^{[2
]}

Trkola, Alexandra ^{[1
]}

机构：

[1] Univ Zurich, Inst Med Virol, CH-8057 Zurich, Switzerland

[2] ETH, Inst Integrat Biol, CH-8092 Zurich, Switzerland

[3] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

TRENDS IN MICROBIOLOGY | 2015年 / 23卷 / 12期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; ENVELOPE GLYCOPROTEIN TRIMERS; SUPERRESOLUTION MICROSCOPY; NEUTRALIZING ANTIBODIES; INFLUENZA HEMAGGLUTININ; MEDIATED FUSION; VESICLE FUSION; FITNESS COST; ENV TRIMERS; BINDING;

D O I：

10.1016/j.tim.2015.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HIV-1 infection starts with fusion of the viral and the host cell membranes, a process mediated by the HIV-1 envelope glycoprotein trimer. The number of trimers required to complete membrane fusion, referred to as HIV-1 entry stoichiometry, remains under debate. A precise definition of HIV-1 entry stoichiometry is important as it reflects the efficacy of the viral entry process and steers the infectivity of HIV-1 virion populations. Initial estimates suggested a unanimous entry stoichiometry across HIV-1 strains while recent findings showed that HIV-1 strains can differ in entry stoichiometry. Here, we review current analyses of HIV-1 entry stoichiometry and point out future research directions to further define the interplay between entry stoichiometry, virus entry fitness, transmission, and susceptibility to antibody neutralization.

引用

页码：763 / 774

页数：12

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