Importance and Evidence of Extent of Resection in Glioblastoma

被引:26
作者
Wykes, Victoria [1 ,2 ]
Zisakis, Athanasios [2 ]
Irimia, Mihaela [2 ]
Ughratdar, Ismail [2 ]
Sawlani, Vijay [3 ]
Watts, Colin [1 ,2 ]
机构
[1] Univ Birmingham, Coll Med & Dent Sci, Inst Canc & Genom Sci, 2nd Floor,IBR West Extens Room 2-17, Birmingham B15 2TT, W Midlands, England
[2] Univ Hosp Birmingham NHS Fdn Trust, Dept Neurosurg, Birmingham, W Midlands, England
[3] Univ Hosp Birmingham NHS Fdn Trust, Dept Radiol, Birmingham, W Midlands, England
关键词
glioblastoma; extent of resection; survival; gross total resection; supramaximal resection; RESIDUAL TUMOR VOLUME; GROSS TOTAL RESECTION; RECURRENT GLIOBLASTOMA; SURGICAL RESECTION; BRAIN-TUMORS; INTRAOPERATIVE MRI; ADJUVANT TEMOZOLOMIDE; 5-AMINOLEVULINIC ACID; CELL INFILTRATION; MALIGNANT GLIOMA;
D O I
10.1055/s-0040-1701635
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Maximal safe resection is an essential part of the multidisciplinary care of patients with glioblastoma. A growing body of data shows that gross total resection is an independent prognostic factor associated with improved clinical outcome. The relationship between extent of glioblastoma (GB) resection and clinical benefit depends critically on the balance between cytoreduction and avoiding neurologic morbidity. The definition of the extent of tumor resection, how this is best measured pre- and postoperatively, and its relation to volume of residual tumor is still discussed. We review the literature supporting extent of resection in GB, highlighting the importance of a standardized definition and measurement of extent of resection to allow greater collaboration in research projects and trials. Recent developments in neurosurgical techniques and technologies focused on maximizing extent of resection and safety are discussed.
引用
收藏
页码:75 / 86
页数:12
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