Generation of three induced pluripotent stem cell lines from type 2 diabetic patients with ocular complications

被引：2

作者：

Chu, Edward Po-Fan ^{[1
]}

Cho, Candy Hsin-Hua ^{[1
]}

Lee, Wen-Jane ^{[2
]}

Lee, I-Te ^{[3
]}

Cheng, I-Fen ^{[1
]}

Kuo, Tzu-Chien ^{[1
,4
]}

Chen, Ruei-Ying ^{[4
]}

Sheu, Wayne Huey-Herng ^{[3
]}

Shen, Chia-Ning ^{[1
,4
]}

机构：

[1] Acad Sinica, Genom Res Ctr, Taipei, Taiwan

[2] Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan

[3] Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan

[4] Natl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei, Taiwan

来源：

STEM CELL RESEARCH | 2020年 / 49卷

关键词：

D O I：

10.1016/j.scr.2020.102109

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Retinopathy is a well-known ocular complication that occurs in patients with type 2 diabetes (T2D). Recent evidence also indicates that diabetic patients have an increased prevalence of dry eye syndrome. However, the etiologies of both diabetic retinopathy (DR) and dry eye disease are complex, and their associations with T2D remains to be fully understood. Patient-derived human induced pluripotent stem cells (hiPSCs) enable the generation of disease-specific retinal tissues such as retinal pigment epithelium and lacrimal gland to model disease pathogenesis. Here, we describe the establishment of three hiPSC lines from T2D patients with PDR or dry eye disease.

引用

页数：5

共 5 条

[1] Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss [J].