Prognostic significance of hepatocyte growth factor and c-MET expression in patients with diffuse large B-cell lymphoma

被引：30

作者：

Kawano, R

Ohshima, K

Karube, K

Yamaguchi, T

Kohno, S

Suzumiya, J

Kikuchi, M

Tamura, K

机构：

[1] Fukuoka Univ, Sch Med, Dept Pathol, Jonan Ku, Fukuoka 8140180, Japan

[2] Fukuoka Univ, Sch Med, Dept Internal Med 1, Fukuoka 8140180, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2004年 / 127卷 / 03期

关键词：

diffuse large B-cell lymphoma; hepatocyte growth factor; c-MET; prognosis;

D O I：

10.1111/j.1365-2141.2004.05197.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The expression and prognostic significance of hepatocyte growth factor (HGF) and its receptor c-MET (MET proto-oncogene) was analysed in 96 cases of diffuse large B-cell lymphoma (DLBCL). Tissue sections were immunohistochemically stained for HGF and c-Met. The prognosis of HGF-positive and c-Met-positive cases was significantly worse than negative cases (HGF: P = 0.0036; c-Met: P = 0.0002). In addition, in the low-risk international prognostic index group, HGF-negative and c-Met-negative cases had a significantly better prognosis than positive cases (HGF: P = 0.0009; c-Met: P < 0.0001). Our results suggest that HGF/c-MET is a useful clinical marker of prognosis for patients with DLBCL.

引用

页码：305 / 307

页数：3

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