Diversity in CD8+ T cell differentiation

被引：60

作者：

Parish, Ian A. ^{[1
]}

Kaech, Susan M. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 03期

关键词：

CHRONIC VIRAL-INFECTION; CUTTING EDGE; IN-VIVO; MEMORY CELLS; TERMINAL DIFFERENTIATION; DELETIONAL TOLERANCE; TRANSCRIPTION FACTOR; MOLECULAR SIGNATURE; PERIPHERAL DELETION; CROSS-PRESENTATION;

D O I：

10.1016/j.coi.2009.05.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8(+) T cells are key effector cells of the adaptive immune system, however their activity must be tightly regulated to allow pathogen clearance whilst preventing immunopathology and autoimmunity. In this review, we summarise the diversity of responses that CD8(+) T cells make to antigenic stimulation with a focus on how CD8(+) T cell responses are regulated to achieve different immune outcomes. In particular, we discuss phenotypic diversity during tolerance induction as well as signals that drive effector and memory cell differentiation in response to infection.

引用

页码：291 / 297

页数：7

共 50 条

[21] Motility Matters: How CD8+ T-Cell Trafficking Influences Effector and Memory Cell Differentiation
Farsakoglu, Yagmur
McDonald, Bryan
Kaech, Susan M.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2021, 13 (08):
[22] Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1
Zhou, Xinyuan
Yu, Shuyang
Zhao, Dong-Mei
Harty, John T.
Badovinac, Vladimir P.
Xue, Hai-Hui
IMMUNITY, 2010, 33 (02) : 229 - 240
[23] Surviving the crash: Transitioning from effector to memory CD8+ T cell
D'Cruz, Louise M.
Rubinstein, Mark P.
Goldrath, Ananda W.
SEMINARS IN IMMUNOLOGY, 2009, 21 (02) : 92 - 98
[24] FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity
Delpoux, Arnaud
Lai, Chen-Yen
Hedrick, Stephen M.
Doedens, Andrew L.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (42) : E8865 - E8874
[25] mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
Pollizzi, Kristen N.
Patel, Chirag H.
Sun, Im-Hong
Oh, Min-Hee
Waickman, Adam T.
Wen, Jiayu
Delgoffe, Greg M.
Powell, Jonathan D.
JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (05) : 2090 - 2108
[26] Agonistic Anti-CD40 Enhances the CD8+ T Cell Response during Vesicular Stomatitis Virus Infection
Zickovich, Julianne M.
Meyer, Susan I.
Yagita, Hideo
Obar, Joshua J.
PLOS ONE, 2014, 9 (08):
[27] Global transcriptional characterization of CD8+ T cell memory
Boettcher, Jan
Knolle, Percy A.
SEMINARS IN IMMUNOLOGY, 2015, 27 (01) : 4 - 9
[28] Origin of CD8+ effector and memory T cell subsets
Stemberger, Christian
Neuenhahn, Michael
Buchholz, Veit R.
Busch, Dirk H.
CELLULAR & MOLECULAR IMMUNOLOGY, 2007, 4 (06) : 399 - 405
[29] Epigenetics and CD8+ T cell memory*
Montacchiesi, Gaia
Pace, Luigia
IMMUNOLOGICAL REVIEWS, 2022, 305 (01) : 77 - 89
[30] Hepatocytes and IL-15: A Favorable Microenvironment for T Cell Survival and CD8+ T Cell Differentiation
Correia, Margareta P.
Cardoso, Elsa M.
Pereira, Carlos F.
Neves, Rui
Uhrberg, Markus
Arosa, Fernando A.
JOURNAL OF IMMUNOLOGY, 2009, 182 (10) : 6149 - 6159

← 1 2 3 4 5 →